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Surround suppression in mouse auditory cortex underlies auditory edge detection.
Gilday, Omri David; Praegel, Benedikt; Maor, Ido; Cohen, Tav; Nelken, Israel; Mizrahi, Adi.
Afiliación
  • Gilday OD; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Praegel B; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Maor I; Department of Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Cohen T; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Nelken I; Department of Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Mizrahi A; Department of Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel.
PLoS Comput Biol ; 19(1): e1010861, 2023 01.
Article en En | MEDLINE | ID: mdl-36656876
Surround suppression (SS) is a fundamental property of sensory processing throughout the brain. In the auditory system, the early processing stream encodes sounds using a one dimensional physical space-frequency. Previous studies in the auditory system have shown SS to manifest as bandwidth tuning around the preferred frequency. We asked whether bandwidth tuning can be found around frequencies away from the preferred frequency. We exploited the simplicity of spectral representation of sounds to study SS by manipulating both sound frequency and bandwidth. We recorded single unit spiking activity from the auditory cortex (ACx) of awake mice in response to an array of broadband stimuli with varying central frequencies and bandwidths. Our recordings revealed that a significant portion of neuronal response profiles had a preferred bandwidth that varied in a regular way with the sound's central frequency. To gain insight into the possible mechanism underlying these responses, we modelled neuronal activity using a variation of the "Mexican hat" function often used to model SS. The model accounted for response properties of single neurons with high accuracy. Our data and model show that these responses in ACx obey simple rules resulting from the presence of lateral inhibitory sidebands, mostly above the excitatory band of the neuron, that result in sensitivity to the location of top frequency edges, invariant to other spectral attributes. Our work offers a simple explanation for auditory edge detection and possibly other computations of spectral content in sounds.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Auditiva Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: PLoS Comput Biol Asunto de la revista: BIOLOGIA / INFORMATICA MEDICA Año: 2023 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Auditiva Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: PLoS Comput Biol Asunto de la revista: BIOLOGIA / INFORMATICA MEDICA Año: 2023 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos