Augmentation of postresection mucosal hyperplasia by plerocercoid growth factor (PGF). Analog of human growth hormone.
Dig Dis Sci
; 32(11): 1275-80, 1987 Nov.
Article
en En
| MEDLINE
| ID: mdl-3665682
Postresection villus hyperplasia is a major compensatory mechanism in the short-bowel patient. Substances capable of augmenting postresection mucosal hyperplasia could have therapeutic implications. Human growth hormone (hGH) and human growth hormone releasing factor (hGHRF) stimulate growth of the gastrointestinal tract; however, the diabetogenic actions of growth hormone limit its usefulness in clinical practice. Plerocercoid larvae of the tapeworm Spirometra mansonoides produce an analog of hGH void of diabetogenic side effects. We assessed effects of plerocercoid growth factor (PGF) on mucosal adaptation following 70% proximal jejunoileal resection in young rats. Mucosal weight, DNA, protein, and total sucrase activity per centimeter of bowel were increased in resected PGF-treated animals compared to resected controls. We conclude PGF augments intrinsic postresection mucosal hyperplasia following extensive intestinal resection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormona del Crecimiento
/
Sustancias de Crecimiento
/
Péptidos y Proteínas de Señalización Intercelular
/
Mucosa Intestinal
Límite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos