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Determinants of oxidative stress among indigenous populations in Northern Laos: Trace element exposures and dietary patterns.
Mizuno, Yuki; Inaba, Yohei; Masuoka, Hiroaki; Kibe, Mihoko; Kosaka, Satoko; Natsuhara, Kazumi; Hirayama, Kazuhiro; Inthavong, Nouhak; Kounnavong, Sengchanh; Tomita, Shinsuke; Umezaki, Masahiro.
Afiliación
  • Mizuno Y; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: mizuno@humeco.m.u-tokyo.ac.jp.
  • Inaba Y; Department of Environmental Health, National Institute of Public Health, Saitama, Japan. Electronic address: inaba.y.aa@niph.go.jp.
  • Masuoka H; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. Electronic address: hiroaki.masuoka@riken.jp.
  • Kibe M; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: mihoko.k@humeco.m.u-tokyo.ac.jp.
  • Kosaka S; Department of Public Health & Nursing, Nagasaki University, Nagasaki, Japan. Electronic address: skosaka@nagasaki-u.ac.jp.
  • Natsuhara K; Faculty of Nursing, Toho University, Tokyo, Japan. Electronic address: kazumi.natsuhara@med.toho-u.ac.jp.
  • Hirayama K; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. Electronic address: akazu@g.ecc.u-tokyo.ac.jp.
  • Inthavong N; Lao Tropical and Public Health Institute, Ministry of Health, Vientiane, Lao Democratic People's Republic.
  • Kounnavong S; Lao Tropical and Public Health Institute, Ministry of Health, Vientiane, Lao Democratic People's Republic.
  • Tomita S; Graduate School of Environmental Studies, Nagoya University, Nagoya, Japan. Electronic address: tomishing@nagoya-u.jp.
  • Umezaki M; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: umezaki@humeco.m.u-tokyo.ac.jp.
Sci Total Environ ; 868: 161516, 2023 Apr 10.
Article en En | MEDLINE | ID: mdl-36646220
OBJECTIVES: To investigate determinants of oxidative stress in an indigenous population, we examined associations of trace element exposures and dietary patterns with three oxidative stress-related biomarkers among indigenous populations in Northern Laos. METHODS: This cross-sectional study included 341 adults from three villages with different levels of modernization. We used three oxidative stress-related biomarkers: urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-isoprostane concentrations, which were measured using liquid chromatography-tandem mass spectrometry, and blood telomere lengths, which were measured using a quantitative polymerase chain reaction method. We used multilevel analysis to examine associations of urinary arsenic, cadmium, and selenium concentrations, their interaction terms, and wild-plant-food scores (principal component scores calculated from food consumption frequencies) with oxidative stress-related biomarkers. RESULTS: Urinary arsenic and cadmium concentrations were positively associated with urinary 8-isoprostane concentrations. Urinary selenium concentrations were positively associated with urinary 8-OHdG concentrations. Interaction terms ([arsenic or cadmium] × selenium) showed negative associations with urinary 8-OHdG and 8-isoprostane concentrations, respectively. Urinary cadmium concentrations were negatively associated with telomere lengths. Wild-plant-food scores did not exhibit associations with oxidative stress-related biomarkers. CONCLUSION: Our findings imply that exposure to arsenic and cadmium is associated with greater oxidative lipid damage, whereas selenium may attenuate arsenic-induced oxidative DNA damage and cadmium-induced oxidative lipid damage. Cadmium exposure may accelerate telomere attrition. Trace element exposure may be a determinant of oxidative stress among indigenous populations in Northern Laos.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsénico / Selenio / Oligoelementos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: Asia Idioma: En Revista: Sci Total Environ Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsénico / Selenio / Oligoelementos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: Asia Idioma: En Revista: Sci Total Environ Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos