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ß-Catenin-activated inflammatory hepatocellular adenoma with pigmentation and atypical features: a case report.
Wakasa, Yusuke; Toyoki, Yoshikazu; Kusumi, Tomomi; Kameyama, Yuma; Odagiri, Tadashi; Jin, Hiroyuki; Nakai, Makoto; Aoki, Kazunori; Kawashima, Hiroaki; Endo, Masaaki.
Afiliación
  • Wakasa Y; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan. wa1022ka@yahoo.co.jp.
  • Toyoki Y; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan.
  • Kusumi T; Department of Pathology, Aomori City Hospital, Aomori, Japan.
  • Kameyama Y; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan.
  • Odagiri T; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan.
  • Jin H; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan.
  • Nakai M; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan.
  • Aoki K; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan.
  • Kawashima H; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan.
  • Endo M; Department of General Surgery, Aomori City Hospital, 1-14-20, Katta, Aomori, 030-0821, Japan.
Clin J Gastroenterol ; 16(2): 237-243, 2023 Apr.
Article en En | MEDLINE | ID: mdl-36640247
Hepatocellular adenomas are rare diseases, defined as benign liver neoplasms composed of cells with hepatocellular differentiation. Differential diagnosis of hepatocellular adenoma from other lesions, including focal nodular hyperplasia and hepatocellular carcinoma, is crucial to determine treatment strategy. We describe a case of ß-catenin-activated inflammatory hepatocellular adenoma with malignant transformation. A 50-year-old man with a suspected liver tumor, based on abdominal ultrasonography findings, was referred to our hospital. Contrast-enhanced computed tomography and magnetic resonance imaging revealed a liver tumor in S2 which was enhanced in the arterial phase to the delayed phase. Based on diagnostic imaging findings, hepatocellular adenoma or focal nodular hyperplasia was suspected. We considered the possibility of malignant potential because of the enlargement of the lesion. Thus, we performed a laparoscopic hepatectomy. Histological examination showed pigment deposition in the hepatocytes, which was determined to be lipofuscin. Mild nuclear swelling and atypia in the tumor area indicated nodular growth. Based on the histological and immunohistochemical findings, the diagnosis was ꞵ-catenin-activated inflammatory hepatocellular adenoma with atypical features. The imaging features of hepatocellular adenoma and focal nodular hyperplasia are similar, but if the tumor tends to grow, surgical treatment should be performed because of the possibility of malignant hepatocellular adenoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Adenoma de Células Hepáticas / Carcinoma Hepatocelular / Hiperplasia Nodular Focal / Neoplasias Hepáticas Tipo de estudio: Diagnostic_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Clin J Gastroenterol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Adenoma de Células Hepáticas / Carcinoma Hepatocelular / Hiperplasia Nodular Focal / Neoplasias Hepáticas Tipo de estudio: Diagnostic_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Clin J Gastroenterol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón