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Feline primary nonhematopoietic malignant liver tumours: A multicenter retrospective study (2000-2021).
Brandstetter, Viktoria; Schmidt, Jarno M; Findji, Laurent; Selmic, Laura E; Murgia, Daniela; de Mello Souza, Carlos H; Liehmann, Lea M; L'Eplattenier, Henry; Tichy, Alexander; Vincenti, Simona.
Afiliación
  • Brandstetter V; Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
  • Schmidt JM; Department of Oncology, Small Animal Clinic Hofheim, Hofheim, Germany.
  • Findji L; Surgical Department, Fitzpatrick Referrals Oncology and Soft Tissue, Guildford, UK.
  • Selmic LE; Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
  • Murgia D; Surgical Department, Dick White Referrals, Cambridgeshire, UK.
  • de Mello Souza CH; Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA.
  • Liehmann LM; Department of Small Animal Surgery, Ophthalmology, Dentistry and Physiotherapy, University of Veterinary Medicine Vienna, Vienna, Austria.
  • L'Eplattenier H; Department of Soft Tissue Surgery, Southfields Veterinary Specialists, Laindon, UK.
  • Tichy A; Department of Biomedical Sciences, Platform Bioinformatics and Biostatistics, University of Veterinary Medicine Vienna, Vienna, Austria.
  • Vincenti S; Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Vet Comp Oncol ; 21(2): 191-199, 2023 Jun.
Article en En | MEDLINE | ID: mdl-36635958
There is scant literature on primary nonhematopoietic malignant liver tumours (PMLT) in cats. In this retrospective study, medical data of 40 cats diagnosed with PMLT were reviewed over a period of 22 years (2000-2021). The most frequent epithelial tumours were hepatocellular (42.5%) and bile duct carcinomas (32.5%), only six (15%) cats had mesenchymal tumours. The median age was 13 years and clinical signs commonly included ano-/hyporexia (62.5%), apathy/lethargy (52.5%), weight loss (42.5%) and vomiting (35%). At initial diagnosis, metastases were confirmed in 1 (2.5%) and suspected in three (7.5%) cats. Massive was the most frequent morphology (75%). Most intrahepatic tumours were left-sided (54.2%) with the left medial lobe being primarily affected (25%). Extrahepatic tumours were rare (5%). In 34 (85%) cats, liver lobectomy was performed (surgery group), four (10%) were treated palliatively (non-surgery group), and two (5%) received no treatment. Intraoperative complications occurred in 11.8% with four (15.4%) postoperative deaths. Recurrence was detected in 28.6% at a median of 151 days (range, 79-684 days), while postoperative metastases were suspected in 21.4% at a median of 186 days (range, 79-479 days). The median survival time (MST) was significantly longer in cats of the surgery group (375 days) than in the non-surgery group (16 days) (p = .002). MST was 868 days for hepatocellular compared to 270 days for bile duct carcinomas (p = .06). In summary, liver lobectomy is associated with prolonged survival times and good prognosis in cats with hepatocellular, and an acceptable prognosis in cats with bile duct carcinoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Enfermedades de los Gatos / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Vet Comp Oncol Asunto de la revista: MEDICINA VETERINARIA / NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Enfermedades de los Gatos / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Vet Comp Oncol Asunto de la revista: MEDICINA VETERINARIA / NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido