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Establishment of multicenter COVID-19 therapeutics preclinical test system in Republic of Korea.
Noh, Hyuna; Yoon, Suhyeon; Kim, Sung-Hee; Kim, Jiseon; Seo, Jung Seon; Kim, Jeong Jin; Park, In Ho; Oh, Jooyeon; Bae, Joon-Yong; Lee, Gee Eun; Woo, Sun-Je; Seo, Sun-Min; Kim, Na-Won; Lee, Youn Woo; Jang, Hui Jeong; Hong, Seung-Min; An, Se-Hee; Lyoo, Kwang-Soo; Yeom, Minjoo; Lee, Hanbyeul; Jung, Bud; Yoon, Sun-Woo; Kang, Jung-Ah; Seok, Sang-Hyuk; Lee, Yu Jin; Kim, Seo Yeon; Kim, Young Been; Hwang, Ji-Yeon; On, Dain; Lim, Soo-Yeon; Kim, Sol Pin; Jang, Ji Yun; Lee, Ho; Kim, Kyoungmi; Lee, Hyo-Jung; Kim, Hong Bin; Kim, Sun Bean; Park, Jun Won; Jeong, Dae Gwin; Song, Daesub; Choi, Kang-Seuk; Lee, Ho-Young; Choi, Yang-Kyu; Choi, Jung-Ah; Song, Manki; Park, Man-Seong; Seo, Jun-Young; Shin, Jeon-Soo; Yun, Jun-Won; Nam, Ki Taek.
Afiliación
  • Noh H; Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic of Korea.
  • Yoon S; Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic of Korea.
  • Kim SH; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Kim J; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Seo JS; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Kim JJ; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Park IH; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Oh J; Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Bae JY; Department of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
  • Lee GE; Department of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
  • Woo SJ; Science Unit, International Vaccine Institute, Seoul, 08826, Republic of Korea.
  • Seo SM; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
  • Kim NW; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
  • Lee YW; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, 13488, Republic of Korea.
  • Jang HJ; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, 13488, Republic of Korea.
  • Hong SM; Laboratory of Avian Diseases, BK21 plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.
  • An SH; Laboratory of Avian Diseases, BK21 plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.
  • Lyoo KS; Korea Zoonosis Research Institute, Chonbuk National University, Iksan, 54531, Republic of Korea.
  • Yeom M; Department of Pharmacy, College of Pharmacy, Korea University, Sejong, 30019, Republic of Korea.
  • Lee H; Department of Pharmacy, College of Pharmacy, Korea University, Sejong, 30019, Republic of Korea.
  • Jung B; Department of Pharmacy, College of Pharmacy, Korea University, Sejong, 30019, Republic of Korea.
  • Yoon SW; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
  • Kang JA; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
  • Seok SH; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, ChunCheon, 24341, Republic of Korea.
  • Lee YJ; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, ChunCheon, 24341, Republic of Korea.
  • Kim SY; Preclinical Research Center, Seoul National University Bundang Hospital, Seongnam, 13488, Republic of Korea.
  • Kim YB; Preclinical Research Center, Seoul National University Bundang Hospital, Seongnam, 13488, Republic of Korea.
  • Hwang JY; Preclinical Research Center, Seoul National University Bundang Hospital, Seongnam, 13488, Republic of Korea.
  • On D; Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic of Korea; Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National Univ
  • Lim SY; Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic of Korea.
  • Kim SP; Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic of Korea.
  • Jang JY; Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Gyeonggi, 10408, Republic of Korea; College of Pharmacy, Dongguk University, Seoul, 04620, Republic of Korea.
  • Lee H; Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Gyeonggi, 10408, Republic of Korea.
  • Kim K; Department of Biomedical Sciences and Department of Physiology, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
  • Lee HJ; Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, 13620, Republic of Korea.
  • Kim HB; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, 13620, Republic of Korea.
  • Kim SB; Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
  • Park JW; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, ChunCheon, 24341, Republic of Korea.
  • Jeong DG; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
  • Song D; Department of Pharmacy, College of Pharmacy, Korea University, Sejong, 30019, Republic of Korea.
  • Choi KS; Laboratory of Avian Diseases, BK21 plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.
  • Lee HY; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, 13488, Republic of Korea.
  • Choi YK; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
  • Choi JA; Science Unit, International Vaccine Institute, Seoul, 08826, Republic of Korea.
  • Song M; Science Unit, International Vaccine Institute, Seoul, 08826, Republic of Korea.
  • Park MS; Department of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
  • Seo JY; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Shin JS; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; Department of M
  • Yun JW; Laboratory of Veterinary Toxicology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea. Electronic address: jwyun@snu.ac.kr.
  • Nam KT; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. Electronic address: kitaek@yuhs.ac.
Pulm Pharmacol Ther ; 80: 102189, 2023 06.
Article en En | MEDLINE | ID: mdl-36634813
Throughout the recent COVID-19 pandemic, South Korea led national efforts to develop vaccines and therapeutics for SARS-CoV-2. The project proceeded as follows: 1) evaluation system setup (including Animal Biosafety Level 3 (ABSL3) facility alliance, standardized nonclinical evaluation protocol, and laboratory information management system), 2) application (including committee review and selection), and 3) evaluation (including expert judgment and reporting). After receiving 101 applications, the selection committee reviewed pharmacokinetics, toxicity, and efficacy data and selected 32 final candidates. In the nonclinical efficacy test, we used golden Syrian hamsters and human angiotensin-converting enzyme 2 transgenic mice under a cytokeratin 18 promoter to evaluate mortality, clinical signs, body weight, viral titer, neutralizing antibody presence, and histopathology. These data indicated eight new drugs and one repositioned drug having significant efficacy for COVID-19. Three vaccine and four antiviral drugs exerted significant protective activities against SARS-CoV-2 pathogenesis. Additionally, two anti-inflammatory drugs showed therapeutic effects on lung lesions and weight loss through their mechanism of action but did not affect viral replication. Along with systematic verification of COVID-19 animal models through large-scale studies, our findings suggest that ABSL3 multicenter alliance and nonclinical evaluation protocol standardization can promote reliable efficacy testing against COVID-19, thus expediting medical product development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Pulm Pharmacol Ther Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Pulm Pharmacol Ther Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido