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Blood urea nitrogen to creatinine ratio is associated with physical frailty in older-aged Chinese: a cross-sectional study.
Chen, Xiao-Xin; Chen, Zuo-Xi; Zhou, Wu-Jie; Wang, Yong; Su, Jia; Zhou, Qiang.
Afiliación
  • Chen XX; No. 23 Ward of Nursing Department of the First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, 325035, Zhejiang, China.
  • Chen ZX; Department of Orthopedic Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, 75 Jinxiu Road, Wenzhou, 325027, Zhejiang, China.
  • Zhou WJ; Department of Orthopedic Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, 75 Jinxiu Road, Wenzhou, 325027, Zhejiang, China.
  • Wang Y; Department of Orthopedic Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, 75 Jinxiu Road, Wenzhou, 325027, Zhejiang, China.
  • Su J; Department of Orthopedic Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, 75 Jinxiu Road, Wenzhou, 325027, Zhejiang, China.
  • Zhou Q; Department of Orthopedic Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, 75 Jinxiu Road, Wenzhou, 325027, Zhejiang, China. zhou_qiang30@sina.com.
Aging Clin Exp Res ; 35(3): 581-589, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36629995
BACKGROUND: The relationship between the ratio of blood urea nitrogen to creatinine (BUN/Cr) and physical frailty in elderly patients remains unclear. The study aims to investigate the association between the BUN/Cr ratio and physical frailty in the elderly Chinese population. METHODS: In this cross-sectional analysis, the clinical data of 5213 participants from 2015 were selected from the China Health and Retirement Longitudinal Study (CHARLS). The demographic variables (including age and gender) and health behavior (including smoking and drinking history), anthropometric (including systolic and diastolic blood pressure, waist circumference (WC), etc.), physical performances (i.e., grip strength, repeated chair stands, etc.), and biochemical indicators (i.e., blood urea nitrogen (BUN), creatinine(Cr), total cholesterol (TC), triglycerides (TG), etc.) were measured. The association between the BUN/Cr ratio and physical frailty was analyzed. RESULTS: After adjusting for potential confounding factors, smooth curve fitting showed a linear relationship between the BUN/Cr ratio and grip strength, a non-linear relationship between the BUN/Cr ratio, and repeated chair-rising time. The fully adjusted linear regression results showed a negative association between the BUN/Cr ratio and grip strength. In the multivariate, piecewise linear regression, when the BUN/Cr ratio was greater than 18.60, the repeated chair-rising time increased with the increase in BUN/Cr ratio (ß = 0.046, 95%CI 0.025, 0.066; p < 0.001). However, we did not observe a significant correlation when the BUN/Cr ratio was less than 18.60 (ß = -0.007, 95%CI -0.046, 0.032; p = 0.717). CONCLUSION: This study demonstrated that the BUN/Cr ratio might be associated with physical frailty in older-aged Chinese, and this association requires further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragilidad / Pueblos del Este de Asia Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: Aging Clin Exp Res Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragilidad / Pueblos del Este de Asia Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: Aging Clin Exp Res Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania