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PANCREATIC SOLID-PSEUDOPAPILLARY NEOPLASM IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS.
Meira-Júnior, José Donizeti; Yogolare, Gustavo Gonçalves; Magalhães, Daniel de Paiva; Namur, Guilherme Naccache; Campos, Fabio Guilherme; Segatelli, Vanderlei; Nahas, Sergio Carlos; Jukemura, Jose.
Afiliación
  • Meira-Júnior JD; Universidade de São Paulo, Faculty of Medicine, University Hospital, Gastroenterology Department, Digestive Surgery Division - São Paulo (SP), Brazil.
  • Yogolare GG; Universidade de São Paulo, Faculty of Medicine, University Hospital, Gastroenterology Department, Digestive Surgery Division - São Paulo (SP), Brazil.
  • Magalhães DP; Universidade de São Paulo, Faculty of Medicine, University Hospital, Gastroenterology Department, Digestive Surgery Division - São Paulo (SP), Brazil.
  • Namur GN; Universidade de São Paulo, Faculty of Medicine, University Hospital, Gastroenterology Department, Digestive Surgery Division - São Paulo (SP), Brazil.
  • Campos FG; Universidade de São Paulo, Faculty of Medicine, University Hospital, Gastroenterology Department, Digestive Surgery Division - São Paulo (SP), Brazil.
  • Segatelli V; Universidade de São Paulo, Faculty of Medicine, University Hospital, Pathology Department - São Paulo (SP), Brasil.
  • Nahas SC; Universidade de São Paulo, Faculty of Medicine, University Hospital, Gastroenterology Department, Digestive Surgery Division - São Paulo (SP), Brazil.
  • Jukemura J; Universidade de São Paulo, Faculty of Medicine, University Hospital, Gastroenterology Department, Digestive Surgery Division - São Paulo (SP), Brazil.
Arq Bras Cir Dig ; 35: e1718, 2023.
Article en En | MEDLINE | ID: mdl-36629695
BACKGROUND: Solid pseudopapillary neoplasm of the pancreas is an uncommon pancreatic tumor, which is more frequent in young adult women. Familial adenomatous polyposis is a genetic condition associated with colorectal cancer that also increases the risk of developing other tumors as well. AIM: The aim of this study was to discuss the association of familial adenomatous polyposis with solid pseudopapillary neoplasm of the pancreas, which is very rare. METHODS: We report two cases of patients with familial adenomatous polyposis who developed solid pseudopapillary neoplasm of the pancreas of the pancreas and were submitted to laparoscopic pancreatic resections with splenic preservation (one male and one female). RESULTS: ß-catenin and Wnt signaling pathways have been found to play an important role in the tumorigenesis of solid pseudopapillary neoplasm of the pancreas, and their constitutive activation due to adenomatous polyposis coli gene inactivation in familial adenomatous polyposis may explain the relationship between familial adenomatous polyposis and solid pseudopapillary neoplasm of the pancreas. CONCLUSION: Colonic resection must be prioritized, and a minimally invasive approach is preferred to minimize the risk of developing desmoid tumor. Pancreatic resection usually does not require extensive lymphadenectomy for solid pseudopapillary neoplasm of the pancreas, and splenic preservation is feasible.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Poliposis Adenomatosa del Colon Límite: Adult / Female / Humans / Male Idioma: En Revista: Arq Bras Cir Dig Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Poliposis Adenomatosa del Colon Límite: Adult / Female / Humans / Male Idioma: En Revista: Arq Bras Cir Dig Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil