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Cellular mechanisms underlying extraordinary sulfide tolerance in a crustacean holobiont from hydrothermal vents.
Chou, Pei-Hsuan; Hu, Marian Y; Guh, Ying-Jey; Wu, Guan-Chung; Yang, Shan-Hua; Tandon, Kshitij; Shao, Yi-Ta; Lin, Li-Yih; Chen, Chi; Tseng, Kuang-Yu; Wang, Min-Chen; Zhang, Cheng-Mao; Han, Bor-Cheng; Lin, Ching-Chun; Tang, Sen-Lin; Jeng, Ming-Shiou; Chang, Ching-Fong; Tseng, Yung-Che.
Afiliación
  • Chou PH; Marine Research Station (MRS), Institute of Cellular and Organismic Biology, Academia Sinica, I-Lan County, Taiwan.
  • Hu MY; Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.
  • Guh YJ; Marine Research Station (MRS), Institute of Cellular and Organismic Biology, Academia Sinica, I-Lan County, Taiwan.
  • Wu GC; Department of Aquaculture, National Taiwan Ocean University, Keelung, Taiwan.
  • Yang SH; Center of Excellence for the Oceans National Taiwan Ocean University, Keelung, Taiwan.
  • Tandon K; Institute of Fisheries Science, National Taiwan University, Taipei City, Taiwan.
  • Shao YT; Biodiversity Research Center, Academia Sinica, Taipei City, Taiwan.
  • Lin LY; Institute of Marine Biology, National Taiwan Ocean University, Keelung, Taiwan.
  • Chen C; Department of Life Science, National Taiwan Normal University, Taipei City, Taiwan.
  • Tseng KY; Doctoral Degree Program in Marine Biotechnology, National Taiwan Ocean University and Academia Sinica, Taipei City, Taiwan.
  • Wang MC; Department of Life Science, Tunghai University, Taichung, Taiwan.
  • Zhang CM; Marine Research Station (MRS), Institute of Cellular and Organismic Biology, Academia Sinica, I-Lan County, Taiwan.
  • Han BC; Biodiversity Research Center, Academia Sinica, Taipei City, Taiwan.
  • Lin CC; School of Public Health, Taipei Medical College, Taipei, Taiwan.
  • Tang SL; Biomedical Translation Research Center, Academia Sinica, Taipei City, Taiwan.
  • Jeng MS; Biodiversity Research Center, Academia Sinica, Taipei City, Taiwan.
  • Chang CF; Biodiversity Research Center, Academia Sinica, Taipei City, Taiwan.
  • Tseng YC; Center of Excellence for the Oceans National Taiwan Ocean University, Keelung, Taiwan.
Proc Biol Sci ; 290(1990): 20221973, 2023 01 11.
Article en En | MEDLINE | ID: mdl-36629118
The shallow-water hydrothermal vent system of Kueishan Island has been described as one of the world's most acidic and sulfide-rich marine habitats. The only recorded metazoan species living in the direct vicinity of the vents is Xenograpsus testudinatus, a brachyuran crab endemic to marine sulfide-rich vent systems. Despite the toxicity of hydrogen sulfide, X. testudinatus occupies an ecological niche in a sulfide-rich habitat, with the underlying detoxification mechanism remaining unknown. Using laboratory and field-based experiments, we characterized the gills of X. testudinatus that are the major site of sulfide detoxification. Here sulfide is oxidized to thiosulfate or bound to hypotaurine to generate the less toxic thiotaurine. Biochemical and molecular analyses demonstrated that the accumulation of thiosulfate and hypotaurine is mediated by the sodium-independent sulfate anion transporter (SLC26A11) and taurine transporter (Taut), which are expressed in gill epithelia. Histological and metagenomic analyses of gill tissues demonstrated a distinct bacterial signature dominated by Epsilonproteobacteria. Our results suggest that thiotaurine synthesized in gills is used by sulfide-oxidizing endo-symbiotic bacteria, creating an effective sulfide-buffering system. This work identified physiological mechanisms involving host-microbe interactions that support life of a metazoan in one of the most extreme environments on our planet.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Braquiuros / Respiraderos Hidrotermales Límite: Animals Idioma: En Revista: Proc Biol Sci Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Braquiuros / Respiraderos Hidrotermales Límite: Animals Idioma: En Revista: Proc Biol Sci Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido