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Development of SARS-CoV-2 specific IgG and IgA antibodies in serum and milk with different SARS-COV-2 vaccines in lactating women.
Lechosa-Muñiz, Carolina; Paz-Zulueta, María; Irure-Ventura, Juan; Mendez-Legaza, Jose Manuel; Cuesta González, Rocío; Gómez-Acebo, Inés; López-Hoyos, Marcos; Llorca, Javier; Cabero-Pérez, María Jesús.
Afiliación
  • Lechosa-Muñiz C; Departamento de Enfermería, Universidad de Cantabria, Santander, Spain.
  • Paz-Zulueta M; Breastfeeding Coordinator, IBCLC, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain.
  • Irure-Ventura J; Departamento de Enfermería, Universidad de Cantabria, Santander, Spain. maria.paz@unican.es.
  • Mendez-Legaza JM; IDIVAL- Grupo de Investigación en Derecho Sanitario y Bioética, GRIDES, Cantabria, Spain. maria.paz@unican.es.
  • Cuesta González R; Department of Immunology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
  • Gómez-Acebo I; Department of Microbiology, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain.
  • López-Hoyos M; Department of Pediatrics, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain.
  • Llorca J; Departamento de Ciencias Médicas y Quirúrgicas. Universidad de Cantabria, Santander, Spain.
  • Cabero-Pérez MJ; IDIVAL, Cantabria, Spain.
Int Breastfeed J ; 18(1): 3, 2023 01 11.
Article en En | MEDLINE | ID: mdl-36627706
BACKGROUND: Our main objective was to determine the evolution of IgG and IgA antibodies directed against SARS-CoV-2 protein S in the blood of lactating women and in breast milk. METHODS: A cohort of 110 uninfected and vaccinated breastfeeding women was followed-up for 6 months at the Marqués de Valdecilla University Hospital, Spain, in 2020. An additional group of 23 breastfeeding mothers who had no previously documented infection and had not been vaccinated against SARS-CoV-2 were included as a control group. The antibodies in blood and breast milk and their evolution at 6 months post-vaccination were analysed. RESULTS: One hundred ten breastfeeding mothers were included; 70 women (63.6%) were vaccinated with two doses of BNT162b2, 20 women (18.2%) received two doses of mRNA-1273, and 20 women (18.2%) received a single dose of ChAdOx1-S. No evidence of differences between concentrations of antibodies was found according to the type of vaccine, with the exception of serum IgA antibodies, which was higher in women vaccinated with mRNA-1273: mean [95%CI]: 0.05 AU/mL [0.03,0.06] with mRNA-1273, 0.02 AU/mL [0.01,0.03] with BNT162b2 and 0.01 AU/mL [0.00,0.03] with ChAdOx1-S, ANOVA p value = 0.03. The lack of difference between vaccines was also found when anti-S1 specific IgG in serum and breast milk were measured. CONCLUSIONS: In lactating women vaccinated against COVID-19, anti-SARS-CoV-2 antibodies can be detected in both serum and breastmilk 6 months after receiving the second dose, although their concentrations decreased when compared with concentrations reached immediately after vaccination.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / COVID-19 Límite: Female / Humans Idioma: En Revista: Int Breastfeed J Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / COVID-19 Límite: Female / Humans Idioma: En Revista: Int Breastfeed J Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido