Your browser doesn't support javascript.
loading
Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and Healthy Controls.
Matthews, Sarah W; Plantinga, Anna; Burr, Robert; Cain, Kevin C; Savidge, Tor; Kamp, Kendra; Heitkemper, Margaret M.
Afiliación
  • Matthews SW; School of Nursing, University of Washington, Seattle, WA, USA.
  • Plantinga A; Williams College, Williamstown, MA, USA.
  • Burr R; School of Nursing, University of Washington, Seattle, WA, USA.
  • Cain KC; Department of Biostatistics and Office for Nursing Research, School of Nursing, University of Washington, Seattle, WA, USA.
  • Savidge T; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
  • Kamp K; Department of Pathology, Texas Children's Microbiome Center, Texas Children's Hospital, Houston, TX, USA.
  • Heitkemper MM; School of Nursing, University of Washington, Seattle, WA, USA.
Biol Res Nurs ; 25(3): 436-443, 2023 07.
Article en En | MEDLINE | ID: mdl-36624571
Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction with multifaceted pathophysiology. Prior studies have demonstrated higher rates of vitamin D deficiency in individuals with IBS compared to healthy controls (HC), as well as associations of vitamin D concentration with IBS symptoms. A systematic review of 10 mouse and 14 human studies reported a positive association between vitamin D (serum levels and supplementation) and beta diversity of gut microbiome in a variety of conditions. The present retrospective case-control study aimed to compare vitamin D (25(OH)D) plasma concentrations and gut microbiome composition in adult women with IBS (n=99) and HC (n=62). Plasma concentrations of 25(OH)D were assessed using the Endocrine Society Guidelines definition of vitamin D deficiency (25(OH)D <20 ng/ml) and insufficiency (25(OH)D >20-<30 ng/ml). 16S rRNA microbiome gene sequencing data was available for 39 HC and 62 participants with IBS. Genus-level Bifidobacterium and Lactobacillus and phylum-level Firmicutes and Bacteroidetes relative abundances were extracted from microbiome profiles. Results showed vitamin D deficiency in 40.3% (n=25) vs. 41.4% (n=41), and insufficiency 33.9% (n=21) vs. 34.3% (n=34) in the HCs vs. IBS groups, respectively. The odds of IBS did not differ depending on 25(OH)D status (p=0.75 for deficient, p=0.78 for insufficient), and the average plasma vitamin D concentration did not differ between IBS (mean 24.8 ng/ml) and HCs (mean 25.1 ng/ml; p=0.57). We did not find evidence of an association between plasma 25(OH)D concentration and richness, Shannon index, Simpson index or specific bacterial abundances in either HCs or the IBS group.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Síndrome del Colon Irritable / Microbioma Gastrointestinal Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Animals / Female / Humans Idioma: En Revista: Biol Res Nurs Asunto de la revista: ENFERMAGEM / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Síndrome del Colon Irritable / Microbioma Gastrointestinal Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Animals / Female / Humans Idioma: En Revista: Biol Res Nurs Asunto de la revista: ENFERMAGEM / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos