Loss of small GTPase Rab7 activation in prion infection negatively affects a feedback loop regulating neuronal cholesterol metabolism.

Cherry, Pearl; Lu, Li; Shim, Su Yeon; Ebacher, Vincent; Tahir, Waqas; Schatzl, Hermann M; Hannaoui, Samia; Gilch, Sabine

Cherry, Pearl; Lu, Li; Shim, Su Yeon; Ebacher, Vincent; Tahir, Waqas; Schatzl, Hermann M; Hannaoui, Samia; Gilch, Sabine.

Afiliación

Cherry P; Calgary Prion Research Unit, Department of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Lu L; Calgary Prion Research Unit, Department of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Shim SY; Calgary Prion Research Unit, Department of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Ebacher V; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Tahir W; Calgary Prion Research Unit, Department of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Schatzl HM; Calgary Prion Research Unit, Department of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Hannaoui S; Calgary Prion Research Unit, Department of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Gilch S; Calgary Prion Research Unit, Department of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address: sgi

J Biol Chem ; 299(2): 102883, 2023 02.

Article en En | MEDLINE | ID: mdl-36623732

Asunto(s)

Hipercolesterolemia; Proteínas de Unión al GTP Monoméricas; Enfermedades por Prión; Animales; Ratones; Colesterol/metabolismo; Activación Enzimática; Retroalimentación; Hipercolesterolemia/etiología; Hipercolesterolemia/fisiopatología; Lipoproteínas LDL/metabolismo; Proteínas de Unión al GTP Monoméricas/genética; Proteínas de Unión al GTP Monoméricas/metabolismo; Neuronas/metabolismo; Enfermedades por Prión/metabolismo; Priones/metabolismo; Proteínas PrPSc/genética; Proteínas PrPSc/metabolismo

Palabras clave

Rab7; cholesterol metabolism; low-density lipoprotein (LDL); prion; ubiquitination

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades por Prión / Proteínas de Unión al GTP Monoméricas / Hipercolesterolemia Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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