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Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19.
Rice, Christopher M; Lewis, Philip; Ponce-Garcia, Fernando M; Gibbs, Willem; Groves, Sarah; Cela, Drinalda; Hamilton, Fergus; Arnold, David; Hyams, Catherine; Oliver, Elizabeth; Barr, Rachael; Goenka, Anu; Davidson, Andrew; Wooldridge, Linda; Finn, Adam; Rivino, Laura; Amulic, Borko.
Afiliación
  • Rice CM; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK christopher.rice@bristol.ac.uk.
  • Lewis P; University of Bristol Proteomics Facility, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Ponce-Garcia FM; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Gibbs W; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Groves S; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Cela D; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Hamilton F; Academic Respiratory Unit, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.
  • Arnold D; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Hyams C; Academic Respiratory Unit, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.
  • Oliver E; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Barr R; Academic Respiratory Unit, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.
  • Goenka A; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Davidson A; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Wooldridge L; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Finn A; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Rivino L; Bristol Veterinary School, Faculty of Health Sciences, University of Bristol, Bristol, UK.
  • Amulic B; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
Life Sci Alliance ; 6(2)2023 02.
Article en En | MEDLINE | ID: mdl-36622345
Neutrophils are vital in defence against pathogens, but excessive neutrophil activity can lead to tissue damage and promote acute respiratory distress syndrome. COVID-19 is associated with systemic expansion of immature neutrophils, but the functional consequences of this shift to immaturity are not understood. We used flow cytometry to investigate activity and phenotypic diversity of circulating neutrophils in acute and convalescent COVID-19 patients. First, we demonstrate hyperactivation of immature CD10- subpopulations in severe disease, with elevated markers of secondary granule release. Partially activated immature neutrophils were detectable 12 wk post-hospitalisation, indicating long term myeloid dysregulation in convalescent COVID-19 patients. Second, we demonstrate that neutrophils from moderately ill patients down-regulate the chemokine receptor CXCR2, whereas neutrophils from severely ill individuals fail to do so, suggesting an altered ability for organ trafficking and a potential mechanism for induction of disease tolerance. CD10- and CXCR2hi neutrophil subpopulations were enriched in severe disease and may represent prognostic biomarkers for the identification of individuals at high risk of progressing to severe COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Interleucina-8B / COVID-19 / Neutrófilos Límite: Humans Idioma: En Revista: Life Sci Alliance Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Interleucina-8B / COVID-19 / Neutrófilos Límite: Humans Idioma: En Revista: Life Sci Alliance Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos