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Emerging Mutual Regulatory Roles between m6A Modification and microRNAs.
Mei, Zongqin; Mou, Yahao; Zhang, Nan; Liu, Xiaoyu; He, Zuoshun; Gu, Shiyan.
Afiliación
  • Mei Z; Institute of Preventive Medicine, School of Public Health, Dali University, No. 22 Wanhua Road, Dali 671000, China.
  • Mou Y; Institute of Preventive Medicine, School of Public Health, Dali University, No. 22 Wanhua Road, Dali 671000, China.
  • Zhang N; Institute of Preventive Medicine, School of Public Health, Dali University, No. 22 Wanhua Road, Dali 671000, China.
  • Liu X; Institute of Preventive Medicine, School of Public Health, Dali University, No. 22 Wanhua Road, Dali 671000, China.
  • He Z; Institute of Preventive Medicine, School of Public Health, Dali University, No. 22 Wanhua Road, Dali 671000, China.
  • Gu S; Institute of Preventive Medicine, School of Public Health, Dali University, No. 22 Wanhua Road, Dali 671000, China.
Int J Mol Sci ; 24(1)2023 Jan 01.
Article en En | MEDLINE | ID: mdl-36614216
N6-metyladenosine (m6A), one of the most common RNA methylation modifications in mammals, has attracted extensive attentions owing to its regulatory roles in a variety of physiological and pathological processes. As a reversible epigenetic modification on RNAs, m6A is dynamically mediated by the functional interplay among the regulatory proteins of methyltransferases, demethylases and methyl-binding proteins. In recent years, it has become increasingly clear that m6A modification is associated with the production and function of microRNAs (miRNAs). In this review, we summarize the specific kinds of m6A modification methyltransferases, demethylases and methyl-binding proteins. In particular, we focus on describing the roles of m6A modification and its regulatory proteins in the production and function of miRNAs in a variety of pathological and physiological processes. More importantly, we further discuss the mediating mechanisms of miRNAs in m6A modification and its regulatory proteins during the occurrence and development of various diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza