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The effect of aromatase inhibitor on controlled ovarian stimulation for oocyte cryopreservation in adolescent and young cancer patients.
Suzuki, Reiko; Horage-Okutsu, Yuki; Kawahara, Tai; Nakamura, Kentaro; Shiraishi, Eriko; Iwahata, Hideyuki; Suzuki-Takahashi, Yuki; Sugishita, Yodo; Takae, Seido; Suzuki, Nao.
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  • Suzuki R; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
  • Horage-Okutsu Y; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
  • Kawahara T; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
  • Nakamura K; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
  • Shiraishi E; Department of Obstetrics and Gynecology, The Jikei University school of medicine, Tokyo, Japan.
  • Iwahata H; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
  • Suzuki-Takahashi Y; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
  • Sugishita Y; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
  • Takae S; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
  • Suzuki N; Department of Obstetrics and Gynecology, Saint Marianna University School of Medicine, Kawasaki, Japan.
J Obstet Gynaecol Res ; 49(3): 973-979, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36606606
AIM: To determine the impact of aromatase inhibitor (AI) use in oocyte cryopreservation among Japanese adolescent and young adult (AYA) cancer patients for fertility preservation, we evaluated the oocyte cryopreservation outcomes following AI therapy in combination with the follicular phase start (FPS) and random start (RS) protocols. METHODS: This retrospective study included 81 cycles of controlled ovarian stimulation (COS) among 73 AYA patients with cancer who underwent oocyte cryopreservation to maintain fertility. The outcome measures were the total number of matured oocytes that were retrieved and cryopreserved, as well as their maturation rates. The AI (+) and AI (-) groups were compared using the RS and FPS protocols. RESULTS: Our results showed that the combined use of AI and COS decreases serum E2 levels and maintains the number of retrieved and cryopreserved mature oocytes. We also confirmed the efficacy of the RS protocol, which was found to have comparable outcomes to that of the FPS protocol in both AI (+) and AI (-) groups. CONCLUSION: The combined use of AI and COS is beneficial for oocyte cryopreservation in patients with estrogen-sensitive cancer, regardless of the menstrual cycle phase of COS initiation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preservación de la Fertilidad / Neoplasias Tipo de estudio: Guideline / Observational_studies Límite: Female / Humans Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preservación de la Fertilidad / Neoplasias Tipo de estudio: Guideline / Observational_studies Límite: Female / Humans Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia