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Longer duration of initial invasive mechanical ventilation is still a crucial risk factor for moderate-to-severe bronchopulmonary dysplasia in very preterm infants: a multicentrer prospective study.
Dou, Cong; Yu, Yong-Hui; Zhuo, Qing-Cui; Qi, Jian-Hong; Huang, Lei; Ding, Yan-Jie; Yang, De-Juan; Li, Li; Li, Dan; Wang, Xiao-Kang; Wang, Yan; Qiao, Xin; Zhang, Xiang; Zhang, Bing-Jin; Jiang, Hai-Yan; Li, Zhong-Liang; Reddy, Simmy.
Afiliación
  • Dou C; Department of Neonatology, Maternal and Child Health Care Hospital of Shandong Province, Shandong University, Jinan, 250014, China.
  • Yu YH; Department of Neonatology, Shandong Provincial Hospital affiliated to Shandong First Medical University, HuaiYin District, No. 324, Jingwu Road, Jinan, 250021, China. alice20402@126.com.
  • Zhuo QC; Department of Neonatology, Shandong Provincial Hospital, Shandong University, HuaiYin District, No. 324, Jingwu Road, Jinan, 250021, China. alice20402@126.com.
  • Qi JH; Department of Neonatology, Qilu Hospital of Shandong University, Jinan, 250012, China.
  • Huang L; Department of Neonatology, Shandong Provincial Hospital affiliated to Shandong First Medical University, HuaiYin District, No. 324, Jingwu Road, Jinan, 250021, China.
  • Ding YJ; Department of Neonatology, Shandong Provincial Maternal and Child Health Care Hospital, Jinan, 250014, China.
  • Yang DJ; Department of Neonatology, Yantai Yuhuangding Hospital, Yantai, 264000, China.
  • Li L; Department of Neonatology, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China.
  • Li D; Department of Neonatology, Linyi People's Hospital, Linyi, 276000, China.
  • Wang XK; Department of Neonatology, Liaocheng People's Hospital, Liaocheng, 252000, China.
  • Wang Y; Department of Neonatology, Shandong Provincial Hospital affiliated to Shandong First Medical University, HuaiYin District, No. 324, Jingwu Road, Jinan, 250021, China.
  • Qiao X; Department of Neonatology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, China.
  • Zhang X; Department of Neonatology, Jinan Maternity and Child Healthcare Hospital, Jinan, 250001, China.
  • Zhang BJ; Department of Neonatology, Hebei Petro China Central Hospital, Langfang, 065000, China.
  • Jiang HY; Department of Neonatology, Shengli Olifield Central Hospital, Dongying, 257000, China.
  • Li ZL; Department of Neonatology, The Third Hospital of Baogang Group, Baotou, 014000, China.
  • Reddy S; Department of Neonatology, W.F. Maternal and Child Health Hospital, Weifang, 261011, China.
World J Pediatr ; 19(6): 577-585, 2023 Jun.
Article en En | MEDLINE | ID: mdl-36604390
OBJECTIVES: We aimed to evaluate the risk factors for moderate-to-severe bronchopulmonary dysplasia (BPD) and focus on discussing its relationship with the duration of initial invasive mechanical ventilation (IMV) in very preterm neonates less than 32 weeks of gestational age (GA). METHODS: We performed a prospective cohort study involving infants born at 23-31 weeks of GA who were admitted to 47 different neonatal intensive care unit (NICU) hospitals in China from January 2018 to December 2021. Patient data were obtained from the Sina-northern Neonatal Network (SNN) Database. RESULTS: We identified 6538 very preterm infants, of whom 49.5% (3236/6538) received initial IMV support, and 12.6% (823/6538) were diagnosed with moderate-to-severe BPD symptoms. The median duration of initial IMV in the moderate-to-severe BPD group was 26 (17-41) days, while in the no or mild BPD group, it was 6 (3-10) days. The incidence rate of moderate-to-severe BPD and the median duration of initial IMV were quite different across different GAs. Multivariable logistic regression analysis showed that the onset of moderate-to-severe BPD was significantly associated with the duration of initial IMV [adjusted odds ratio (AOR): 1.97; 95% confidence interval (CI): 1.10-2.67], late-onset neonatal sepsis (LONS), and patent ductus arteriosus (PDA). CONCLUSION: In this multicenter cohort study, the duration of initial IMV was still relatively long in very premature infants, and the longer duration of initial IMV accounts for the increased risk of moderate-to-severe BPD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia Broncopulmonar / Enfermedades del Prematuro Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Infant / Newborn Idioma: En Revista: World J Pediatr Asunto de la revista: PEDIATRIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia Broncopulmonar / Enfermedades del Prematuro Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Infant / Newborn Idioma: En Revista: World J Pediatr Asunto de la revista: PEDIATRIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza