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Neurocognitive impairment in multiple sclerosis and its association with thiol-disulfide homeostasis and ischemia-modified albumin.
Can Demirdögen, Birsen; Kiliç, Osman Oguzhan; Yilmaz, Ata Ayhan; Mungan, Semra; Neselioglu, Salim; Erel, Özcan.
Afiliación
  • Can Demirdögen B; Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey.
  • Kiliç OO; Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey.
  • Yilmaz AA; Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey.
  • Mungan S; Neurology Clinic, Ankara City Hospital, Ankara, Turkey.
  • Neselioglu S; Department of Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
  • Erel Ö; Department of Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
J Neurosci Res ; 101(4): 508-523, 2023 04.
Article en En | MEDLINE | ID: mdl-36602284
This study aimed to assess the possible association between cognitive impairment and two important biochemical biomarkers of oxidative stress, thiol-disulfide homeostasis (TDH), and ischemia-modified albumin (IMA) in patients with multiple sclerosis (MS). This study included 85 patients with MS (38 treatment-naïve relapsing-remitting MS (RRMS), 31 RRMS on fingolimod therapy, and 16 secondary progressive MS (SPMS)) and 33 healthy controls. Cognitive evaluation was carried out by applying the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) test battery and the scores were adjusted for age and years of education. Plasma TDH was assessed using an automated method and plasma IMA levels were determined using the cobalt-albumin binding assay. Plasma native thiol and total thiol levels were significantly decreased in patients with SPMS when compared with the naïve patients and healthy controls. Cognitive impairment was detected in 47.4% of naïve patients, 64.5% of patients on fingolimod therapy, and 80% of patients with SPMS. Naïve patients or patients on fingolimod therapy who were cognitively impaired had significantly decreased levels of native thiol and total thiol compared to the cognitively normal patients. Logistic regression analysis revealed total thiol and native thiol to be significantly associated with cognitive impairment in naïve patients and patients on fingolimod therapy. Significant correlations were determined between BICAMS scores, TDH, IMA, clinical indices of disease severity (EDSS and MSSS), and magnetic resonance imaging parameters. This study has shown for the first time that plasma TDH parameters are associated with cognitive impairment in MS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Neurosci Res Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Neurosci Res Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos