Your browser doesn't support javascript.
loading
Engineered bacteria for augmented in situ tumor vaccination.
Shen, Xinyuan; Zhu, Chaojie; Liu, Xutao; Zheng, Hanqi; Wu, Qing; Xie, Jijin; Huang, Hao; Liao, Ziyan; Shi, Jiaqi; Nan, Kewang; Wang, Junxia; Mao, Xuming; Gu, Zhen; Li, Hongjun.
Afiliación
  • Shen X; Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. guzhen@zju.edu.cn.
  • Zhu C; Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. guzhen@zju.edu.cn.
  • Liu X; Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
  • Zheng H; Department of Bioengineering, University of California, Los Angeles, California 90095, USA.
  • Wu Q; Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. guzhen@zju.edu.cn.
  • Xie J; Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. guzhen@zju.edu.cn.
  • Huang H; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China.
  • Liao Z; Institute of Pharmaceutical Biotechnology, School of Medicine, Zhejiang University, Hangzhou 310058, China.
  • Shi J; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
  • Nan K; Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. guzhen@zju.edu.cn.
  • Wang J; Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. guzhen@zju.edu.cn.
  • Mao X; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China.
  • Gu Z; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Li H; Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. guzhen@zju.edu.cn.
Biomater Sci ; 11(4): 1137-1152, 2023 Feb 14.
Article en En | MEDLINE | ID: mdl-36601796
In situ tumor vaccination has aroused tremendous interest with its capability for eliciting strong and systemic antitumor immune responses. Unlike traditional cancer vaccines, in situ tumor vaccination avoids the laborious process of tumor antigen identification and can modulate tumor immunosuppressive microenvironment at the same time. In recent years, bacteria have been used as both efficient tumor-targeted delivery vehicles and potent adjuvants. Regarding the rapid development in this area, in this review, we summarize recent advances in the application of bacteria for in situ cancer vaccination. We illustrate the mechanisms of bacteria as both efficient tumor immunogenic cell death inducers and tumor-targeted delivery platforms. Then we comprehensively review the engineering strategies for designing bacteria-based in situ vaccination, including chemical modification, nanotechnology, and genetic engineering. The current dilemma and future directions are discussed at the end of this review.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra el Cáncer / Neoplasias / Antineoplásicos Límite: Humans Idioma: En Revista: Biomater Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra el Cáncer / Neoplasias / Antineoplásicos Límite: Humans Idioma: En Revista: Biomater Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido