Your browser doesn't support javascript.
loading
Whole-brain DTI parameters associated with tau protein and hippocampal volume in Alzheimer's disease.
Magalhães, Thamires Naela Cardoso; Casseb, Raphael Fernandes; Gerbelli, Christian Luiz Baptista; Pimentel-Siva, Luciana Ramalho; Nogueira, Mateus Henrique; Teixeira, Camila Vieira Ligo; Carletti, Ana Flávia Mac Knight; de Rezende, Thiago Junqueira Ribeiro; Joaquim, Helena Passarelli Giroud; Talib, Leda Leme; Forlenza, Orestes Vicente; Cendes, Fernando; Balthazar, Marcio Luiz Figueredo.
Afiliación
  • Magalhães TNC; Department of Neurology and Neuroimaging Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
  • Casseb RF; Brazilian Institute of Neuroscience and Neurotechnology, São Paulo, Brazil.
  • Gerbelli CLB; Department of Neurology and Neuroimaging Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
  • Pimentel-Siva LR; Seaman Family MR Research Center, University of Calgary, Calgary, Canada.
  • Nogueira MH; Department of Neurology and Neuroimaging Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
  • Teixeira CVL; Department of Neurology and Neuroimaging Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
  • Carletti AFMK; Brazilian Institute of Neuroscience and Neurotechnology, São Paulo, Brazil.
  • de Rezende TJR; Department of Neurology and Neuroimaging Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
  • Joaquim HPG; Brazilian Institute of Neuroscience and Neurotechnology, São Paulo, Brazil.
  • Talib LL; Brazilian Institute of Neuroscience and Neurotechnology, São Paulo, Brazil.
  • Forlenza OV; National Institute on Aging, National Institute of Health, Baltimore, Maryland, USA.
  • Cendes F; Department of Neurology and Neuroimaging Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
  • Balthazar MLF; Department of Neurology and Neuroimaging Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Brain Behav ; 13(2): e2863, 2023 02.
Article en En | MEDLINE | ID: mdl-36601694
The causes of the neurodegenerative processes in Alzheimer's disease (AD) are not completely known. Recent studies have shown that white matter (WM) damage could be more severe and widespread than whole-brain cortical atrophy and that such damage may appear even before the damage to the gray matter (GM). In AD, Amyloid-beta (Aß42 ) and tau proteins could directly affect WM, spreading across brain networks. Since hippocampal atrophy is common in the early phase of disease, it is reasonable to expect that hippocampal volume (HV) might be also related to WM integrity. Our study aimed to evaluate the integrity of the whole-brain WM, through diffusion tensor imaging (DTI) parameters, in mild AD and amnestic mild cognitive impairment (aMCI) due to AD (with Aß42 alteration in cerebrospinal fluid [CSF]) in relation to controls; and possible correlations between those measures and the CSF levels of Aß42 , phosphorylated tau protein (p-Tau) and total tau (t-Tau). We found a widespread WM alteration in the groups, and we also observed correlations between p-Tau and t-Tau with tracts directly linked to mesial temporal lobe (MTL) structures (fornix and hippocampal cingulum). However, linear regressions showed that the HV better explained the variation found in the DTI measures (with weak to moderate effect sizes, explaining from 9% to 31%) than did CSF proteins. In conclusion, we found widespread alterations in WM integrity, particularly in regions commonly affected by the disease in our group of early-stage disease and patients with Alzheimer's disease. Nonetheless, in the statistical models, the HV better predicted the integrity of the MTL tracts than the biomarkers in CSF.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Brain Behav Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Brain Behav Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos