Your browser doesn't support javascript.
loading
External validation and update of the J-ACCESS model in an Italian cohort of patients undergoing stress myocardial perfusion imaging.
Petretta, Mario; Megna, Rosario; Assante, Roberta; Zampella, Emilia; Nappi, Carmela; Gaudieri, Valeria; Mannarino, Teresa; Green, Roberta; Cantoni, Valeria; D'Antonio, Adriana; Panico, Mariarosaria; Acampa, Wanda; Cuocolo, Alberto.
Afiliación
  • Petretta M; IRCCS Synlab SDN, Via Gianturco 113, 80142, Naples, Italy.
  • Megna R; Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy.
  • Assante R; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Zampella E; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Nappi C; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Gaudieri V; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Mannarino T; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Green R; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Cantoni V; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • D'Antonio A; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Panico M; Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy.
  • Acampa W; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Cuocolo A; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy. cuocolo@unina.it.
J Nucl Cardiol ; 30(4): 1443-1453, 2023 08.
Article en En | MEDLINE | ID: mdl-36598749
BACKGROUND: Cardiovascular risk models are based on traditional risk factors and investigations such as imaging tests. External validation is important to determine reproducibility and generalizability of a prediction model. We performed an external validation of t the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS) model, developed from a cohort of patients undergoing stress myocardial perfusion imaging. METHODS: We included 3623 patients with suspected or known coronary artery disease undergoing stress single-photon emission computer tomography (SPECT) myocardial perfusion imaging at our academic center between January 2001 and December 2019. RESULTS: In our study population, the J-ACCESS model underestimated the risk of major adverse cardiac events (cardiac death, nonfatal myocardial infarction, and severe heart failure requiring hospitalization) within three-year follow-up. The recalibrations and updated of the model slightly improved the initial performance: C-statistics increased from 0.664 to 0.666 and Brier score decreased from 0.075 to 0.073. Hosmer-Lemeshow test indicated a logistic regression fit only for the calibration slope (P = .45) and updated model (P = .22). In the update model, the intercept, diabetes, and severity of myocardial perfusion defects categorized coefficients were comparable with J-ACCESS. CONCLUSION: The external validation of the J-ACCESS model as well as recalibration models have a limited value for predicting of three-year major adverse cardiac events in our patients. The performance in predicting risk of the updated model resulted superimposable to the calibration slope model.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Imagen de Perfusión Miocárdica / Infarto del Miocardio Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Imagen de Perfusión Miocárdica / Infarto del Miocardio Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos