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Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.
Hamed, Mostafa M; Abdelsamie, Ahmed S; Rox, Katharina; Schütz, Christian; Kany, Andreas M; Röhrig, Teresa; Schmelz, Stefan; Blankenfeldt, Wulf; Arce-Rodriguez, Alejandro; Borrero-de Acuña, José Manuel; Jahn, Dieter; Rademacher, Jessica; Ringshausen, Felix C; Cramer, Nina; Tümmler, Burkhard; Hirsch, Anna K H; Hartmann, Rolf W; Empting, Martin.
Afiliación
  • Hamed MM; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany.
  • Abdelsamie AS; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig Saarbrücken, 66123, Saarbrücken, Germany.
  • Rox K; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany.
  • Schütz C; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig Saarbrücken, 66123, Saarbrücken, Germany.
  • Kany AM; Department of Chemistry of Natural and Microbial Products, Institute of Pharmaceutical and Drug Industries Research, National Research Centre, El-Buhouth St., Dokki, Cairo, 12622, Egypt.
  • Röhrig T; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig Saarbrücken, 66123, Saarbrücken, Germany.
  • Schmelz S; Department of Chemical Biology (CBIO), Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7 Braunschweig, 38124, Saarbrücken, Germany.
  • Blankenfeldt W; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany.
  • Arce-Rodriguez A; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig Saarbrücken, 66123, Saarbrücken, Germany.
  • Borrero-de Acuña JM; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany.
  • Jahn D; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig Saarbrücken, 66123, Saarbrücken, Germany.
  • Rademacher J; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany.
  • Ringshausen FC; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig Saarbrücken, 66123, Saarbrücken, Germany.
  • Cramer N; Department of Structure and Function of Proteins (SFPR), Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7 Braunschweig, 38124, Saarbrücken, Germany.
  • Tümmler B; Department of Structure and Function of Proteins (SFPR), Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7 Braunschweig, 38124, Saarbrücken, Germany.
  • Hirsch AKH; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany.
  • Hartmann RW; Institute of Microbiology, Technische Universität Braunschweig, 38106, Braunschweig, Germany.
  • Empting M; Institute of Microbiology, Technische Universität Braunschweig, 38106, Braunschweig, Germany.
Adv Sci (Weinh) ; 10(5): e2204443, 2023 02.
Article en En | MEDLINE | ID: mdl-36596691
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolonas / Agonismo Inverso de Drogas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolonas / Agonismo Inverso de Drogas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania