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The BNT162b2 vaccine induces humoral and cellular immune memory to SARS-CoV-2 Wuhan strain and the Omicron variant in children 5 to 11 years of age.
Cinicola, Bianca Laura; Piano Mortari, E; Zicari, Anna Maria; Agrati, Chiara; Bordoni, Veronica; Albano, Christian; Fedele, Giorgio; Schiavoni, Ilaria; Leone, Pasqualina; Fiore, Stefano; Capponi, Martina; Conti, Maria Giulia; Petrarca, Laura; Stefanelli, Paola; Spalice, Alberto; Midulla, Fabio; Palamara, Anna Teresa; Quinti, Isabella; Locatelli, Franco; Carsetti, Rita.
Afiliación
  • Cinicola BL; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Piano Mortari E; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Zicari AM; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Agrati C; B cell unit, Immunology Research Area, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • Bordoni V; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Albano C; Department of Pediatric Hematology and Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • Fedele G; Department of Pediatric Hematology and Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • Schiavoni I; B cell unit, Immunology Research Area, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • Leone P; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Fiore S; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Capponi M; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Conti MG; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Petrarca L; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Stefanelli P; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Spalice A; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Midulla F; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Palamara AT; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Quinti I; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Locatelli F; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Carsetti R; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Front Immunol ; 13: 1094727, 2022.
Article en En | MEDLINE | ID: mdl-36591287
SARS-CoV-2 mRNA vaccines prevent severe COVID-19 by generating immune memory, comprising specific antibodies and memory B and T cells. Although children are at low risk of severe COVID-19, the spreading of highly transmissible variants has led to increasing in COVID-19 cases and hospitalizations also in the youngest, but vaccine coverage remains low. Immunogenicity to mRNA vaccines has not been extensively studied in children 5 to 11 years old. In particular, cellular immunity to the wild-type strain (Wuhan) and the cross-reactive response to the Omicron variant of concern has not been investigated. We assessed the humoral and cellular immune response to the SARS-CoV-2 BNT162b2 vaccine in 27 healthy children. We demonstrated that vaccination induced a potent humoral and cellular immune response in all vaccinees. By using spike-specific memory B cells as a measurable imprint of a previous infection, we found that 50% of the children had signs of a past, undiagnosed infection before vaccination. Children with pre-existent immune memory generated significantly increased levels of specific antibodies, and memory T and B cells, directed against not only the wild type virus but also the omicron variant.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Límite: Child / Child, preschool / Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Límite: Child / Child, preschool / Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza