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Insulin-like growth factor-1 stimulates retinal cell proliferation via activation of multiple signaling pathways.
de Figueiredo, Camila Saggioro; Raony, Ícaro; Medina, Simone Vidal; de Mello Silva, Eliezer; Dos Santos, Aline Araujo; Giestal-de-Araujo, Elizabeth.
Afiliación
  • de Figueiredo CS; Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Niterói, 24210-200, Brazil.
  • Raony Í; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
  • Medina SV; Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Niterói, 24210-200, Brazil.
  • de Mello Silva E; Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Niterói, 24210-200, Brazil.
  • Dos Santos AA; Department of Physiology and Pharmacology and Program of Neurosciences, Fluminense Federal University, Niterói, 24210-130, Brazil.
  • Giestal-de-Araujo E; Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Niterói, 24210-200, Brazil.
Curr Res Neurobiol ; 4: 100068, 2023.
Article en En | MEDLINE | ID: mdl-36589675
Insulin-like growth factor-1 (IGF-1) plays critical roles in the development of the central nervous system (CNS), including the retina, regulating cell proliferation, differentiation, and survival. Here, we investigated the role of IGF-1 on retinal cell proliferation using primary cultures from rat neural retina. Our data show that IGF-1 stimulates retinal cell proliferation and regulates the expression of neurotrophic factors, such as interleukin-4 and brain-derived neurotrophic factor. In addition, our results indicates that IGF-1-induced retinal cell proliferation requires activation of multiple signaling pathways, including phosphatidylinositol 3-kinase, protein kinase Src, phospholipase-C, protein kinase C delta, and mitogen-activated protein kinase pathways. We further show that activation of matrix metalloproteinases and epidermal growth factor receptor is also necessary for IGF-1 enhancing retinal cell proliferation. Overall, these results unveil potential mechanisms by which IGF-1 ensures retinal cell proliferation and support the notion that manipulation of IGF-1 signaling may be beneficial in CNS disorders associated with abnormal cell proliferation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Res Neurobiol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Res Neurobiol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos