Structural relationships between the isoenzymes of human placental alkaline phosphatase: a serum factor converts M-PLAP to A- and B-PLAP.

Livingstone, J C; Abu-Hasan, N S; Clegg, R J; Henderson, S J; Marsden, H S; Sutcliffe, R G

Livingstone, J C; Abu-Hasan, N S; Clegg, R J; Henderson, S J; Marsden, H S; Sutcliffe, R G.

Afiliación

Livingstone JC; Institute of Genetics, Glasgow University, UK.

Placenta ; 8(3): 305-18, 1987.

Article en En | MEDLINE | ID: mdl-3658925

RESUMEN

A protein factor has been found in serum which converts the M form of placental alkaline phosphatase (PLAP) to the A and B forms. The identity of the conversion products has been confirmed by analysis of their dimers and polypeptides. Proteolysis is not implicated in this phenomenon. This report establishes microvillous M-PLAP as the precursor of the A and B forms.

Asunto(s)

Fosfatasa Alcalina/aislamiento & purificación; Isoenzimas/aislamiento & purificación; Placenta/enzimología; Fosfatasa Alcalina/sangre; Femenino; Humanos; Isoenzimas/sangre; Microvellosidades/enzimología; Peso Molecular; Embarazo; Conformación Proteica

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Fosfatasa Alcalina / Isoenzimas Límite: Female / Humans / Pregnancy Idioma: En Revista: Placenta Año: 1987 Tipo del documento: Article Pais de publicación: Países Bajos

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