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The gut microbiome is a significant risk factor for future chronic lung disease.
Liu, Yang; Teo, Shu Mei; Méric, Guillaume; Tang, Howard H F; Zhu, Qiyun; Sanders, Jon G; Vázquez-Baeza, Yoshiki; Verspoor, Karin; Vartiainen, Ville A; Jousilahti, Pekka; Lahti, Leo; Niiranen, Teemu; Havulinna, Aki S; Knight, Rob; Salomaa, Veikko; Inouye, Michael.
Afiliación
  • Liu Y; Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Melbourne, Australia; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia. Electronic address: yang.liu2@baker.edu.au.
  • Teo SM; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Centre for Youth Mental Health, University of Melbourn
  • Méric G; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia.
  • Tang HHF; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Zhu Q; School of Life Sciences, Arizona State University, Tempe, Ariz; Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, Ariz.
  • Sanders JG; Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY.
  • Vázquez-Baeza Y; Center for Microbiome Innovation, Jacobs School of Engineering, University of California San Diego, La Jolla, Calif.
  • Verspoor K; School of Computing Technologies, RMIT University, Melbourne, Australia; School of Computing and Information Systems, The University of Melbourne, Melbourne, Australia.
  • Vartiainen VA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Pulmonary Medicine, Heart and Lung Center, Helsinki University Hospital, H
  • Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Lahti L; Department of Computing, University of Turku, Turku, Finland.
  • Niiranen T; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Division of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
  • Havulinna AS; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland, FIMM-HiLIFE, University of Helsinki, Helsinki, Finland.
  • Knight R; Center for Microbiome Innovation, Jacobs School of Engineering, University of California San Diego, La Jolla, Calif; Department of Computer Science and Engineering, University of California San Diego, La Jolla, Calif; Department of Pediatrics, School of Medicine, University of California San Diego,
  • Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Inouye M; Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Melbourne, Australia; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary C
J Allergy Clin Immunol ; 151(4): 943-952, 2023 04.
Article en En | MEDLINE | ID: mdl-36587850
BACKGROUND: The gut-lung axis is generally recognized, but there are few large studies of the gut microbiome and incident respiratory disease in adults. OBJECTIVE: We sought to investigate the association and predictive capacity of the gut microbiome for incident asthma and chronic obstructive pulmonary disease (COPD). METHODS: Shallow metagenomic sequencing was performed for stool samples from a prospective, population-based cohort (FINRISK02; N = 7115 adults) with linked national administrative health register-derived classifications for incident asthma and COPD up to 15 years after baseline. Generalized linear models and Cox regressions were used to assess associations of microbial taxa and diversity with disease occurrence. Predictive models were constructed using machine learning with extreme gradient boosting. Models considered taxa abundances individually and in combination with other risk factors, including sex, age, body mass index, and smoking status. RESULTS: A total of 695 and 392 statistically significant associations were found between baseline taxonomic groups and incident asthma and COPD, respectively. Gradient boosting decision trees of baseline gut microbiome abundance predicted incident asthma and COPD in the validation data sets with mean area under the curves of 0.608 and 0.780, respectively. Cox analysis showed that the baseline gut microbiome achieved higher predictive performance than individual conventional risk factors, with C-indices of 0.623 for asthma and 0.817 for COPD. The integration of the gut microbiome and conventional risk factors further improved prediction capacities. CONCLUSIONS: The gut microbiome is a significant risk factor for incident asthma and incident COPD and is largely independent of conventional risk factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Enfermedad Pulmonar Obstructiva Crónica / Microbioma Gastrointestinal Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Enfermedad Pulmonar Obstructiva Crónica / Microbioma Gastrointestinal Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos