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CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
Li, Yue; You, Cuiping; Liu, Zhenchuan; He, Feng; Zhao, Fuchun; Song, Xiaojie; Xie, Zhongxiang; Wei, Shuai; Yang, Yongfang; Wei, Hongyan; Che, Fengyuan; Yu, Jixu.
Afiliación
  • Li Y; Qingdao University, Qingdao, Shandong, China; Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China.
  • You C; Central Laboratory, Linyi People's Hospital, Linyi, Shandong, China.
  • Liu Z; Department of Neurological Intensive Care Unit, Linyi People's Hospital, Linyi, Shandong, China.
  • He F; Department of Neurological Intensive Care Unit, Linyi People's Hospital, Linyi, Shandong, China.
  • Zhao F; Department of Neurological Intensive Care Unit, Linyi People's Hospital, Linyi, Shandong, China.
  • Song X; Department of Neurological Intensive Care Unit, Linyi People's Hospital, Linyi, Shandong, China.
  • Xie Z; Department of Neurological Intensive Care Unit, Linyi People's Hospital, Linyi, Shandong, China.
  • Wei S; Department of Neurological Intensive Care Unit, Linyi People's Hospital, Linyi, Shandong, China.
  • Yang Y; Rehabilitation department, Linyi People's Hospital, Linyi, Shandong, China.
  • Wei H; Department of Neurological Intensive Care Unit, Linyi People's Hospital, Linyi, Shandong, China.
  • Che F; Central Laboratory, Linyi People's Hospital, Linyi, Shandong, China. Electronic address: fengyuanche2022@163.com.
  • Yu J; Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China. Electronic address: yujixu@163.com.
J Stroke Cerebrovasc Dis ; 32(3): 106974, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36587509
PURPOSE: Many studies have shown that cytochrome P450 (CYP) gene polymorphisms are usually associated with an increased risk of cardiovascular and cerebrovascular diseases. To explore the association of CYP2C8 and CYP2J2 gene polymorphisms with hypertensive intracerebral hemorrhage (HICH) in the Han Chinese population. METHODS: Forty HICH patients and 40 control subjects were recruited for this study. Two single nucleotide polymorphisms (SNP) (rs1058932, rs2275622) in the CYP2C8 gene and two SNPs (rs2271800, rs1155002) in the CYP2J2 gene were selected for genotyping by direct sequencing. Statistical analysis was applied to examine the effect of genetic variation on HICH. RESULTS: We found that variant alleles of CYP2C8 rs1058932 (A) and rs2275622 (C) were both significantly associated with HICH, especially in females. We also found significant associations of CYP2C8 rs1058932 (A) and rs2275622 (C) variant alleles with poor outcomes in HICH patients, especially in males. CONCLUSIONS: CYP2C8 gene polymorphisms might increase the risk of HICH in the Han Chinese population and might lead to poor outcomes. This finding adds to the body of literature supporting novel therapeutic strategies for HICH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Intracraneal Hipertensiva / Citocromo P-450 CYP2J2 Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: J Stroke Cerebrovasc Dis Asunto de la revista: ANGIOLOGIA / CEREBRO Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Intracraneal Hipertensiva / Citocromo P-450 CYP2J2 Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: J Stroke Cerebrovasc Dis Asunto de la revista: ANGIOLOGIA / CEREBRO Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos