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Lipid nanoparticles technology in vaccines: Shaping the future of prophylactic medicine.
Abdellatif, Ahmed A H; Younis, Mahmoud A; Alsowinea, Abdullah F; Abdallah, Emad M; Abdel-Bakky, Mohamed S; Al-Subaiyel, Amal; Hassan, Yasser A H; Tawfeek, Hesham M.
Afiliación
  • Abdellatif AAH; Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah 51452, Kingdom of Saudi Arabia; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. Electronic address: a.abdellatif@qu.edu.sa.
  • Younis MA; Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: mahmoudyounis@aun.edu.eg.
  • Alsowinea AF; Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah 51452, Kingdom of Saudi Arabia. Electronic address: CPHAFS@gmail.com.
  • Abdallah EM; Department of Science Laboratories, College of Science and Arts, Qassim University, Ar Rass 51921 Kingdom of Saudi Arabia. Electronic address: emad100sdl@yahoo.com.
  • Abdel-Bakky MS; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim 52471, Kingdom of Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11884 Egypt. Electronic address: M.AbdelBakky@qu.edu.sa.
  • Al-Subaiyel A; Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah 51452, Kingdom of Saudi Arabia. Electronic address: asbiel@qu.edu.sa.
  • Hassan YAH; Department Psychology, College of Education, Umm Al-Qura University, 21955 Makkah, Kingdom of Saudi Arabia; Department of Psychology, College of Education, South Valley University, Qena, 83523, Egypt. Electronic address: yahassan@uqu.edu.sa.
  • Tawfeek HM; Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: heshamtawfeek@aun.edu.eg.
Colloids Surf B Biointerfaces ; 222: 113111, 2023 Feb.
Article en En | MEDLINE | ID: mdl-36586237
Throughout decades, the intrinsic power of the immune system to fight pathogens has inspired researchers to develop techniques that enable the prevention or treatment of infections via boosting the immune response against the target pathogens, which has led to the evolution of vaccines. The recruitment of Lipid nanoparticles (LNPs) as either vaccine delivery platforms or immunogenic modalities has witnessed a breakthrough recently, which has been crowned with the development of effective LNPs-based vaccines against COVID-19. In the current article, we discuss some principles of such a technology, with a special focus on the technical aspects from a translational perspective. Representative examples of LNPs-based vaccines against cancer, COVID-19, as well as other infectious diseases, autoimmune diseases, and allergies are highlighted, considering the challenges and promises. Lastly, the key features that can improve the clinical translation of this area of endeavor are inspired.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / Nanopartículas / COVID-19 Límite: Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / Nanopartículas / COVID-19 Límite: Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos