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[Leptin mediated activation of group 2 innate lymphocytes aggravates the pathogenesis of allergic rhinitis in obese adults].
Wang, Xiaoqiang; Hu, Guohua; Shen, Yang; Ke, Xia; Kang, Houyong; Hong, Suling.
Afiliación
  • Wang X; Department of Otorhinolaryngology Head and Neck surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. *Corresponding author, E-mail: shachengren111@163.com.
  • Hu G; Department of Otorhinolaryngology Head and Neck surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
  • Shen Y; Department of Otorhinolaryngology Head and Neck surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
  • Ke X; Department of Otorhinolaryngology Head and Neck surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
  • Kang H; Department of Otorhinolaryngology Head and Neck surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
  • Hong S; Department of Otorhinolaryngology Head and Neck surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi ; 38(12): 1118-1124, 2022 Dec.
Article en Zh | MEDLINE | ID: mdl-36585235
Objective To observe the impact of leptin on the activation of group 2 innate lymphocytes (ILC2) in obese adult patients with allergic rhinitis (AR), and investigate its role and significance in the pathogenesis of AR. Methods A total of 70 patients with AR were enrolled in the study and divided into obese AR group and non-obese AR group according to body mass index (BMI), and matched with 30 cases in the healthy control group with no difference in age and gender during the same period. Flow cytometry was used to detect the ratio of ILC2 in peripheral blood mononuclear cells (PBMCs) of each group, real-time quantitative PCR to detect the expression of leptin mRNA, and ELISA to detect the serum leptin. The correlation between leptin and ILC2 was analyzed, and the changes in the ratio of ILC2 and relevant immune indexes in PBMCs of the AR group before and after the intervention of recombinant leptin were observed. Results Compared with healthy control group, the expressions of leptin and ILC2 of the AR group increased significantly, and the level of the obese AR group was significantly higher than that of the non-obese AR group. The expressions of leptin and ILC2 in the obese AR group were positively correlated in a significant manner. After the intervention of recombinant leptin, the ILC2 level of the obese AR group increased significantly. Conclusion The pathogenesis of AR in obese adults is related to its high expression of leptin, and the activation of ILC2 mediated by leptin aggravates its pathogenetic process.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leptina / Rinitis Alérgica Tipo de estudio: Etiology_studies Límite: Adult / Humans Idioma: Zh Revista: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: China
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leptina / Rinitis Alérgica Tipo de estudio: Etiology_studies Límite: Adult / Humans Idioma: Zh Revista: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: China