Cardiomyocyte PAI-1 influences the cardiac transcriptome and limits the extent of cardiac fibrosis in response to left ventricular pressure overload.

Ghosh, Asish K; Kalousdian, Anthony A; Shang, Meng; Lux, Elizabeth; Eren, Mesut; Keating, Anna; Wilsbacher, Lisa D; Vaughan, Douglas E

Ghosh, Asish K; Kalousdian, Anthony A; Shang, Meng; Lux, Elizabeth; Eren, Mesut; Keating, Anna; Wilsbacher, Lisa D; Vaughan, Douglas E.

Afiliación

Ghosh AK; Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: a-ghosh2@northwestern.edu.
Kalousdian AA; Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Shang M; Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lux E; Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Eren M; Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Keating A; Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Wilsbacher LD; Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Vaughan DE; Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: d-vaughan@northwestern.edu.

Cell Signal ; 104: 110555, 2023 04.

Article en En | MEDLINE | ID: mdl-36584735

Asunto(s)

Cardiomiopatías; Miocitos Cardíacos; Ratones; Animales; Miocitos Cardíacos/metabolismo; Miocardio/metabolismo; Inhibidor 1 de Activador Plasminogénico/metabolismo; Transcriptoma; Presión Ventricular; Cardiomiopatías/patología; Fibrosis; Citocinas/metabolismo; Ratones Noqueados; Remodelación Ventricular; Ratones Endogámicos C57BL; Modelos Animales de Enfermedad

Palabras clave

Cardiac fibrosis; Cardiac hypertrophy; Cardiomyocyte; Epigenetic regulators; Inflammation; Metabolism; PAI-1; Transcriptome analysis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Cardiomiopatías Límite: Animals Idioma: En Revista: Cell Signal Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido

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