Activated Hepatic Nuclear Factor-&#954;B in Experimental Colitis Regulates CYP2A5 and Metronidazole Disposition.

Ma, Luyao; Zeng, Wanying; Tan, Zhiyi; Wang, Rui; Yang, Yi; Lin, Shubin; Li, Feng; Wang, Shuai

Activated Hepatic Nuclear Factor-κB in Experimental Colitis Regulates CYP2A5 and Metronidazole Disposition.

Ma, Luyao; Zeng, Wanying; Tan, Zhiyi; Wang, Rui; Yang, Yi; Lin, Shubin; Li, Feng; Wang, Shuai.

Afiliación

Ma L; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Zeng W; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Tan Z; Guangzhou Customs Technology Center, Guangzhou 510623, China.
Wang R; The Third Clinical Medical College, Xinxiang Medical University, Xinxiang 453003, China.
Yang Y; Department of Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Lin S; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Li F; Infectious Diseases Institute, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.
Wang S; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Mol Pharm ; 20(2): 1222-1229, 2023 02 06.

Article en En | MEDLINE | ID: mdl-36583631

Asunto(s)

Hidrocarburo de Aril Hidroxilasas; Colitis; Animales; Ratones; FN-kappa B/metabolismo; Metronidazol/farmacología; Colitis/inducido químicamente; Colitis/tratamiento farmacológico; Colitis/metabolismo; Transducción de Señal; Hígado/metabolismo; Ratones Endogámicos C57BL; Modelos Animales de Enfermedad; Familia 2 del Citocromo P450/genética; Familia 2 del Citocromo P450/metabolismo; Hidrocarburo de Aril Hidroxilasas/efectos adversos; Hidrocarburo de Aril Hidroxilasas/metabolismo

Palabras clave

CYP2A5; NF-κB; colitis; metronidazole; pharmacokinetics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburo de Aril Hidroxilasas / Colitis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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