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Carbohydrate pellets to assess insulin dysregulation in horses.
de Laat, Melody A; Warnken, Tobias; Delarocque, Julien; Reiche, Dania B; Grob, Anne J; Feige, Karsten; Carslake, Harry B; Durham, Andy E; Sillence, Martin N; Thane, Kristen E; Frank, Nicholas; Brojer, Johan; Lindase, Sanna; Sonntag, Johanna.
Afiliación
  • de Laat MA; Faculty of Science, Queensland University of Technology, Brisbane, Queensland, Australia.
  • Warnken T; Boehringer Ingelheim Vetmedica GmbH, Ingelheim, Germany.
  • Delarocque J; Clinic for Horses, University of Veterinary Medicine, Hannover, Germany.
  • Reiche DB; Clinic for Horses, University of Veterinary Medicine, Hannover, Germany.
  • Grob AJ; Boehringer Ingelheim Vetmedica GmbH, Ingelheim, Germany.
  • Feige K; Clinic for Horses, University of Veterinary Medicine, Hannover, Germany.
  • Carslake HB; Clinic for Horses, University of Veterinary Medicine, Hannover, Germany.
  • Durham AE; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Sillence MN; Liphook Equine Hospital, Liphook, UK.
  • Thane KE; Faculty of Science, Queensland University of Technology, Brisbane, Queensland, Australia.
  • Frank N; Department of Comparative Pathobiology, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
  • Brojer J; Department of Comparative Pathobiology, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
  • Lindase S; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Sonntag J; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
J Vet Intern Med ; 37(1): 302-314, 2023 Jan.
Article en En | MEDLINE | ID: mdl-36583553
BACKGROUND: A glycemic challenge test is used for the diagnosis of insulin dysregulation (ID) in horses and ponies. Different forms of the test exist where the administrative route and dose of glucose vary, which makes interpretation of results challenging. HYPOTHESIS/OBJECTIVES: To evaluate the palatability of, and blood glucose and insulin responses to, carbohydrate pellets fed as an oral glucose test (OGT), and to establish the diagnostic threshold for ID when using the pellets. ANIMALS: University and privately-owned horses and ponies (n = 157) comprised of 31 breeds and both sexes. METHODS: Multicenter cohort study. A custom-produced glycemic pellet was offered for free intake at 0.5 g/kg BW soluble carbohydrate and serum insulin and blood glucose concentrations measured before and after (60, 120, and 180 minutes) the pellets were offered. Pellet acceptance and intake time (those that finished within 10 minutes) were determined to assess palatability. RESULTS: The pellets were palatable to 132/157 animals, and ponies found the pellets more (P = .004) palatable than horses. The median intake time (4 [3-6] minutes) was positively correlated with acceptance grade (r = .51; P < .0001). Consumption of the pellets elicited peak blood glucose (6.6 [5.8-7.8] mmol/L) and serum insulin (40.5 [19-99.8] µIU/mL) responses at 120 minutes. At 120 minutes the optimal cut-off was 83 µIU/mL (95% CI: 70-99 µIU/mL) for the IMMULITE 2000XPi assay. CONCLUSIONS AND CLINICAL IMPORTANCE: The pellets were palatable and a suitable, novel carbohydrate source for the OGT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Caballos / Insulina Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Vet Intern Med Asunto de la revista: MEDICINA INTERNA / MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Caballos / Insulina Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Vet Intern Med Asunto de la revista: MEDICINA INTERNA / MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos