High drug loading nanosized amorphous solid dispersion (NASD) with enhanced in vitro solubility and permeability: Benchmarking conventional ASD.

Andrews, Gavin P; Qian, Kaijie; Jacobs, Esther; Jones, David S; Tian, Yiwei

Andrews, Gavin P; Qian, Kaijie; Jacobs, Esther; Jones, David S; Tian, Yiwei.

Afiliación

Andrews GP; School of Pharmacy, Queen's University Belfast, BT9 7BL, United Kingdom.
Qian K; School of Pharmacy, Queen's University Belfast, BT9 7BL, United Kingdom.
Jacobs E; School of Pharmacy, Queen's University Belfast, BT9 7BL, United Kingdom.
Jones DS; School of Pharmacy, Queen's University Belfast, BT9 7BL, United Kingdom.
Tian Y; School of Pharmacy, Queen's University Belfast, BT9 7BL, United Kingdom. Electronic address: y.tian@qub.ac.uk.

Int J Pharm ; 632: 122551, 2023 Feb 05.

Article en En | MEDLINE | ID: mdl-36581107

Asunto(s)

Benchmarking; Povidona; Solubilidad; Liberación de Fármacos; Povidona/química; Permeabilidad; Composición de Medicamentos

Palabras clave

High drug loading; Nanosized amorphous solid dispersion; Permeability enhancement; Polymeric nanoparticles; Solubility enhancement; Twin-screw extrusion; parallel artificial membrane permeability assay (PAMPA)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Povidona / Benchmarking Idioma: En Revista: Int J Pharm Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Países Bajos

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