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Single-center real-world treatment outcomes of ablative fractional laser-assisted photodynamic therapy for actinic keratosis.
Kim, Dong Chan; Han, Hee Jeong; Kim, Seung Il; Park, Bumhee; Kim, You Chan.
Afiliación
  • Kim DC; Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea.
  • Han HJ; Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea.
  • Kim SI; Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Suwon, South Korea.
  • Park B; Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Suwon, South Korea.
  • Kim YC; Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea.
Photodermatol Photoimmunol Photomed ; 39(2): 116-121, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36579473
BACKGROUND: Among various treatment modalities of actinic keratosis (AK), ablative fractional laser-assisted photodynamic therapy (fractional PDT) has shown higher efficacy despite shorter incubation time. However, there are lack of real-world studies on the therapeutic response of ablative PDT for AK and the factors that can predict the therapeutic response. PURPOSE: The aim of this study was to analyze the association between clinical characteristics and treatment outcomes of fractional PDT. METHODS: One hundred fifty-six patients who were histologically diagnosed with AK and treated with fractional PDT were retrospectively reviewed. The Kruskal-Wallis test was used to compare treatment session differences according to grades. RESULTS: In multivariate analysis, the grade 2 category tended to be more clinically nonresponders than the grade 1 (OR, 5.17; 95% CI, 1.011-26.439; p = .048) and the group treated four or more times with ablative fractional laser-assisted PDT were more likely to show no response compared with the single treatment session group (OR, 8.78; 95% CI, 1.355-56.874; p = .023). Treatment sessions were significantly lower in grade 1 (1.72 ± 0.63, mean ± SD) when compared to grades 2 and 3, respectively (2.17 ± 0.76; 2.60 ± 1.60, mean ± SD). Recurrence was highest in grade 2, and most of them occurred after 1 year. CONCLUSION: On average, two treatment sessions are sufficient for AK lesions, but the thicker the lesion, the more treatment sessions may be required. Although there are relatively smaller number of grade 3 patients were included, recurrence was more frequent in higher grade of AK category, which needs special attention to thicker lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Queratosis Actínica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Photodermatol Photoimmunol Photomed Asunto de la revista: ALERGIA E IMUNOLOGIA / DERMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Queratosis Actínica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Photodermatol Photoimmunol Photomed Asunto de la revista: ALERGIA E IMUNOLOGIA / DERMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido