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Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission.
Barrows, Brittani M; Krebs, Shelly J; Jian, Ningbo; Zemil, Michelle; Slike, Bonnie M; Dussupt, Vincent; Tran, Ursula; Mendez-Rivera, Letzibeth; Chang, David; O'Sullivan, Anne Marie; Mann, Brendan; Sanders-Buell, Eric; Shubin, Zhanna; Creegan, Matt; Paquin-Proulx, Dominic; Ehrenberg, Philip; Laurence-Chenine, Agnes; Srithanaviboonchai, Kriengkrai; Thomas, Rasmi; Eller, Michael A; Ferrari, Guido; Robb, Merlin; Rao, Venigalla; Tovanabutra, Sodsai; Polonis, Victoria R; Wieczorek, Lindsay.
Afiliación
  • Barrows BM; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Krebs SJ; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Jian N; Department of Biology, The Catholic University of America, Washington, DC, United States.
  • Zemil M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Slike BM; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Dussupt V; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Tran U; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Mendez-Rivera L; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Chang D; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • O'Sullivan AM; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Mann B; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Sanders-Buell E; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Shubin Z; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Creegan M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Paquin-Proulx D; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Ehrenberg P; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Laurence-Chenine A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Srithanaviboonchai K; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Thomas R; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Eller MA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Ferrari G; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Robb M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Rao V; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Tovanabutra S; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
  • Polonis VR; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
  • Wieczorek L; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Front Immunol ; 13: 1051501, 2022.
Article en En | MEDLINE | ID: mdl-36578481
Introduction: Infants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions. Methods: In this study, we evaluated Fc receptor engagement and ADCC activity of plasma binding antibodies from human immunodeficiency virus-1 (HIV) -infected mothers and to identify factors that may contribute to protection from HIV vertical transmission. Results: HIV-specific binding and Fc receptor engagement of plasma antibodies varied between mothers by transmission status and infants by infection status. Non-transmitting (NT) mothers and HIV-uninfected infants had antibodies with higher neonatal Fc receptor (FcRn) and FcγR engagement, as compared to transmitting (T) mothers and HIV+ infants, respectively. A significant inverse correlation between plasma antibody FcRn and FcγR engagement was observed for T mothers, but not NT mothers. Conversely, a significant direct correlation was observed between plasma antibody FcRn and FcγR engagement for HIV- infants, but not for HIV+ infants. Consequently, we observed significantly higher plasma antibody ADCC potency and breadth in HIV- infants, as compared to HIV+ infants. However, no differences in overall ADCC potency and breadth were observed between mothers. FcRn-engagement of HIV-specific antibodies in both mothers and infants predicted a lack of vertical transmission of HIV. Discussion: This study indicates that HIV-uninfected infants acquire HIV-specific antibodies with greater Fc receptor engagement and thus, greater ADCC capacity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza