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Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway.
Ye, Wei-Wei; Meng, Xiang-Ying; Zhao, Qian; Chen, Jian-Yang; Liu, Cong; Chen, Feng; Zhou, Yong; Wang, Yi.
Afiliación
  • Ye WW; Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.
  • Meng XY; Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.
  • Zhao Q; Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.
  • Chen JY; Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.
  • Liu C; Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.
  • Chen F; Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.
  • Zhou Y; Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.
  • Wang Y; Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.
J Asian Nat Prod Res ; 25(9): 880-889, 2023 Sep.
Article en En | MEDLINE | ID: mdl-36573490
Echinacoside (ECH) is the main compound of Cistanche deserticola, which possesses antioxidant, antitumor, antifatigue, and anti-inflammatory properties. The present study investigated the protective effects of echinacoside on type 2 diabetes mellitus (T2DM)-induced injury in T2DM injury db/db mice model and insulin-resistant LO2 cell model. The results demonstrated that ECH probably alleviated T2DM-induced injury by mediating the AKT pathway, which provided a new direction for the treatment of T2DM-induced injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Proteínas Proto-Oncogénicas c-akt Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Proteínas Proto-Oncogénicas c-akt Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido