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Leishmania infantum (syn. Leishmania chagasi) detection in blood donors living in an endemic area.
Lopes, Elizandra Aparecida de Oliveira; Florencio-Henschel, Patrícia; Jordão, Felipe Trovalim; Sperança, Márcia Aparecida; Martins, Luciamare Perinetti Alves; Suzuki, Rodrigo Buzinaro.
Afiliación
  • Lopes EAO; Department of Parasitology, Marília Medical School, Marília, SP, Brazil.
  • Florencio-Henschel P; Centro de Laboratório Regional IV, Instituto Adolfo Lutz, Marília, SP, Brazil.
  • Jordão FT; Center for Natural and Human Sciences, Federal University of ABC, São Bernardo Do Campo, SP, Brazil.
  • Sperança MA; Center for Natural and Human Sciences, Federal University of ABC, São Bernardo Do Campo, SP, Brazil.
  • Martins LPA; Department of Parasitology, Marília Medical School, Marília, SP, Brazil.
  • Suzuki RB; Faculty of Medicine, University of Marília, Avenida Hygino Muzzy Filho, Zip Code: 17.525-902, Marília, SP, 1001, Brazil. rbsuzuki@gmail.com.
Parasitol Res ; 122(2): 671-674, 2023 Feb.
Article en En | MEDLINE | ID: mdl-36567398
Human visceral leishmaniasis (HVL) is a neglected disease that occurs in 98 countries on five continents, and it is endemic in tropical and subtropical regions. In South America, the etiological agent of HVL is Leishmania infantum (syn. Leishmania chagasi), mainly transmitted through the bite of an infected sandfly female from the genus Lutzomyia. In American HVL endemic areas, the occurrence of asymptomatic infection is common, which contributes to the possibility of L. infantum transmission during a blood transfusion. To know the prevalence of L. infantum asymptomatic infection in blood donors from the microregion of Adamantina, we investigated 324 peripheral blood samples from donors through immunofluorescence (IFAT) and PCR-RFLP techniques. Seven blood samples (2.16%) tested positive for Leishmania by IFAT, and from those, six presented positive results by PCR (85.71%), which were later identified as L. infantum by RFLP. The presence of L. infantum in the peripheral blood of blood donors supported the hypothesis of transmission by blood transfusion and points to the need to include tests for visceral leishmaniasis in blood bank screening tests and pre-storage measures, especially in endemic areas to prevent the exponential increase of HVL by blood transfusion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psychodidae / Leishmania infantum / Leishmaniasis Visceral Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Parasitol Res Asunto de la revista: PARASITOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psychodidae / Leishmania infantum / Leishmaniasis Visceral Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Parasitol Res Asunto de la revista: PARASITOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania