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Qiangguyin inhibited fat accumulation in OVX mice through the p38 MAPK signaling pathway to achieve anti-osteoporosis effects.
Wen, Jingyuan; Bao, Zhengsheng; Li, Lunxin; Liu, Yingquan; Wei, Bing; Ye, Xiaoang; Xu, Huihui; Cui, Longkang; Li, Xuefei; Shen, Gaobo; Fang, Yuan; Zeng, Hanbing; Shen, Zhe; Guo, Enping; Jin, Hongting; Wu, Lianguo.
Afiliación
  • Wen J; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Bao Z; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Li L; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Liu Y; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Wei B; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Ye X; The First Clinical College, Zhejiang Chinese Medical University, Hangzhou, China.
  • Xu H; The First Clinical College, Zhejiang Chinese Medical University, Hangzhou, China.
  • Cui L; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Li X; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Shen G; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Fang Y; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Zeng H; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Shen Z; The First Clinical College, Zhejiang Chinese Medical University, Hangzhou, China.
  • Guo E; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Jin H; The First Clinical College, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: hongtingjin@163.com.
  • Wu L; The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: mdwu8535@126.com.
Biomed Pharmacother ; 158: 114122, 2023 Feb.
Article en En | MEDLINE | ID: mdl-36566522
Postmenopausal osteoporosis (PMOP) is a common bone disease characterized by decreased bone density and increased bone fragility due to decreased estrogen levels. Qiangguyin (QGY) is transformed from the famous traditional Chinese medicine BuShen Invigorating Blood Decoction. In this study, we used QGY to treat PMOP. We observed that QGY significantly reduced fat accumulation in the chondro-osseous junction. However, its specific mechanism of action remains unclear. To determine the specific molecular mechanism of QGY, we explored the pharmacological mechanism by which QGY reduces fat accumulation in the chondro-osseous junction through network pharmacological analysis. The active components and targets related to PMOP and QGY were screened from different databases, forming a composition-target-disease network. Next, a comprehensive analysis platform including protein-protein interaction (PPI) network, Gene Ontology (GO) enrichment analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were established. The results revealed that QGY inhibits adipogenic differentiation by activating the mitogen-activated protein kinase (MAPK) signaling pathway, thus reducing the accumulation of fat in the chondro-osseous junction. For further verification. In vitro and in vivo experiments were carried out. Our data showed that QGY significantly reversed the high expression of fatty acid binding protein 4 (FABP4) and peroxisome proliferator-activated receptor γ (PPARγ). Further, QGY prevents fat accumulation by inhibiting the expression of p38. In summary, the results of this study suggested that QGY-induced phenotypic changes are related to the activation of the p38 MAPK signaling pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Proteína Quinasa 14 Activada por Mitógenos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Proteína Quinasa 14 Activada por Mitógenos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia