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High-dose chemotherapy and autologous stem cell transplantation in primary lymphomatoid granulomatosis of the central nervous system.
Nilius-Eliliwi, Verena; Treiber, Hannes; Seidel, Sabine; Vangala, Deepak B; Schroers, Roland.
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  • Nilius-Eliliwi V; Department of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, In Der Schornau 23-25, 44892, Bochum, Germany.
  • Treiber H; Department of Hematology and Oncology, University of Göttingen, Göttingen, Germany.
  • Seidel S; Department of Neurology, Knappschaftskrankenhaus, Ruhr-University, Bochum, Germany.
  • Vangala DB; Department of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, In Der Schornau 23-25, 44892, Bochum, Germany.
  • Schroers R; Department of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, In Der Schornau 23-25, 44892, Bochum, Germany. Roland.Schroers@rub.de.
J Cancer Res Clin Oncol ; 149(9): 5729-5732, 2023 Aug.
Article en En | MEDLINE | ID: mdl-36566338
Primary lymphomatoid granulomatosis of the CNS (CNS-LG) is a rare lymphoid neoplasia associated Epstein-Barr Virus (EBV) and often accompanied by immunodeficiencies. No treatment standards have been defined yet. However, due to often devastating neurologic sequelae and based on similarities to diffuse large B-cell lymphoma, curative treatment requires intensive therapy protocols resembling protocols applied in CNS lymphoma. Here, the clinical courses and treatments of four primary CNS-LG patients in analogy to aggressive CNS-lymphomas including methotrexate, thiotepa, cytarabine, carmustine, and rituximab are presented. This is the first report on high-dose chemotherapy with CNS-directed drugs and autologous blood stem cell transplantation in primary CNS-LG.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Infecciones por Virus de Epstein-Barr / Enfermedades Virales del Sistema Nervioso Central / Trasplante de Células Madre de Sangre Periférica / Granulomatosis Linfomatoide / Antineoplásicos Tipo de estudio: Guideline Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Cancer Res Clin Oncol Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Infecciones por Virus de Epstein-Barr / Enfermedades Virales del Sistema Nervioso Central / Trasplante de Células Madre de Sangre Periférica / Granulomatosis Linfomatoide / Antineoplásicos Tipo de estudio: Guideline Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Cancer Res Clin Oncol Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania