Nucleolar Stress Response via Ribosomal Protein L11 Regulates Topoisomerase Inhibitor Sensitivity of P53-Intact Cancers.

Ishihara, Yuka; Nakamura, Kiyoshiro; Nakagawa, Shunsuke; Okamoto, Yasuhiro; Yamamoto, Masatatsu; Furukawa, Tatsuhiko; Kawahara, Kohichi

Ishihara, Yuka; Nakamura, Kiyoshiro; Nakagawa, Shunsuke; Okamoto, Yasuhiro; Yamamoto, Masatatsu; Furukawa, Tatsuhiko; Kawahara, Kohichi.

Afiliación

Ishihara Y; Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Nakamura K; Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Nakagawa S; Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Okamoto Y; Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Yamamoto M; Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Furukawa T; Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Kawahara K; Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.

Int J Mol Sci ; 23(24)2022 Dec 15.

Article en En | MEDLINE | ID: mdl-36555627

Asunto(s)

Neoplasias; Proteína p53 Supresora de Tumor; Proteína p53 Supresora de Tumor/genética; Proteína p53 Supresora de Tumor/metabolismo; Proteínas Ribosómicas/metabolismo; Nucléolo Celular/metabolismo; Línea Celular Tumoral; Antibióticos Antineoplásicos/farmacología; ARN Ribosómico/genética; Inhibidores de Topoisomerasa II/farmacología; Inhibidores de Topoisomerasa II/metabolismo; Antraciclinas/farmacología; Proteínas Proto-Oncogénicas c-mdm2/metabolismo; Neoplasias/metabolismo

Palabras clave

RPL11; drug sensitivity; nucleolar stress response; p53; topoisomerase inhibitors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Neoplasias Tipo de estudio: Diagnostic_studies Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza

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