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Genetic Variants and Protective Immunity against SARS-CoV-2.
Rabaan, Ali A; Mutair, Abbas Al; Aljeldah, Mohammed; Shammari, Basim R Al; Sulaiman, Tarek; Alshukairi, Abeer N; Alfaresi, Mubarak; Al-Jishi, Jumana M; Al Bati, Neda A; Al-Mozaini, Maha A; Bshabshe, Ali Al; Almatouq, Jenan A; Abuzaid, Abdulmonem A; Alfaraj, Amal H; Al-Adsani, Wasl; Alabdullah, Mohammed; Alwarthan, Sara; Alsalman, Fatimah; Alwashmi, Ameen S S; Alhumaid, Saad.
Afiliación
  • Rabaan AA; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
  • Mutair AA; College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
  • Aljeldah M; Department of Public Health and Nutrition, The University of Haripur, Haripur 22610, Pakistan.
  • Shammari BRA; Research Center, Almoosa Specialist Hospital, Al-Ahsa 36342, Saudi Arabia.
  • Sulaiman T; College of Nursing, Princess Norah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
  • Alshukairi AN; School of Nursing, Wollongong University, Wollongong, NSW 2522, Australia.
  • Alfaresi M; Nursing Department, Prince Sultan Military College of Health Sciences, Dhahran 33048, Saudi Arabia.
  • Al-Jishi JM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39831, Saudi Arabia.
  • Al Bati NA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39831, Saudi Arabia.
  • Al-Mozaini MA; Infectious Diseases Section, Medical Specialties Department, King Fahad Medical City, Riyadh 12231, Saudi Arabia.
  • Bshabshe AA; College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
  • Almatouq JA; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah 21499, Saudi Arabia.
  • Abuzaid AA; Department of Pathology and Laboratory Medicine, Sheikh Khalifa General Hospital, Umm Al Quwain 499, United Arab Emirates.
  • Alfaraj AH; Department of Pathology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai 505055, United Arab Emirates.
  • Al-Adsani W; Internal Medicine Department, Qatif Central Hospital, Qatif 35342, Saudi Arabia.
  • Alabdullah M; Medical and Clinical Affairs, Rural Health Network, Eastern Health Cluster, Dammam 31444, Saudi Arabia.
  • Alwarthan S; Immunocompromised Host Research Section, Department of Infection and Immunity, King Faisal, Specialist Hospital and Research Centre, Riyadh 11564, Saudi Arabia.
  • Alsalman F; Adult Critical Care Department of Medicine, Division of Adult Critical Care, College of Medicine, King Khalid University, Abha 62561, Saudi Arabia.
  • Alwashmi ASS; Department of Clinical Laboratory Sciences, Mohammed Al-Mana College of Health Sciences, Dammam 34222, Saudi Arabia.
  • Alhumaid S; Medical Microbiology Department, Security Forces Hospital Programme, Dammam 32314, Saudi Arabia.
Genes (Basel) ; 13(12)2022 12 13.
Article en En | MEDLINE | ID: mdl-36553622
The novel coronavirus-19 (SARS-CoV-2), has infected numerous individuals worldwide, resulting in millions of fatalities. The pandemic spread with high mortality rates in multiple waves, leaving others with moderate to severe symptoms. Co-morbidity variables, including hypertension, diabetes, and immunosuppression, have exacerbated the severity of COVID-19. In addition, numerous efforts have been made to comprehend the pathogenic and host variables that contribute to COVID-19 susceptibility and pathogenesis. One of these endeavours is understanding the host genetic factors predisposing an individual to COVID-19. Genome-Wide Association Studies (GWAS) have demonstrated the host predisposition factors in different populations. These factors are involved in the appropriate immune response, their imbalance influences susceptibility or resistance to viral infection. This review investigated the host genetic components implicated at the various stages of viral pathogenesis, including viral entry, pathophysiological alterations, and immunological responses. In addition, the recent and most updated genetic variations associated with multiple host factors affecting COVID-19 pathogenesis are described in the study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / COVID-19 Límite: Humans Idioma: En Revista: Genes (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / COVID-19 Límite: Humans Idioma: En Revista: Genes (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza