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Diabetes-Induced Cardiac Autonomic Neuropathy: Impact on Heart Function and Prognosis.
Sudo, Susumu Z; Montagnoli, Tadeu L; Rocha, Bruna de S; Santos, Aimeé D; de Sá, Mauro P L; Zapata-Sudo, Gisele.
Afiliación
  • Sudo SZ; Programa de Pós-Graduação em Medicina (Cirurgia Geral), Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
  • Montagnoli TL; Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
  • Rocha BS; Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
  • Santos AD; Programa de Pós-Graduação em Cardiologia, Instituto do Coração Edson Saad, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
  • de Sá MPL; Faculdade de Enfermagem, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 22290-180, Brazil.
  • Zapata-Sudo G; Instituto do Coração Edson Saad, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
Biomedicines ; 10(12)2022 Dec 15.
Article en En | MEDLINE | ID: mdl-36552014
Cardiovascular autonomic neuropathy (CAN) is a severe complication of the advance stage of diabetes. More than 50% of diabetic patients diagnosed with peripheral neuropathy will have CAN, with clinical manifestations including tachycardia, severe orthostatic hypotension, syncope, and physical exercise intolerance. Since the prevalence of diabetes is increasing, a concomitant increase in CAN is expected and will reduce quality of life and increase mortality. Autonomic dysfunction is associated with reduced baroreflex sensitivity and impairment of sympathetic and parasympathetic modulation. Various autonomic function tests are used to diagnose CAN, a condition without adequate treatment. It is important to consider the control of glucose level and blood pressure as key factors for preventing CAN progression. However, altered biomarkers of inflammatory and endothelial function, increased purinergic receptor expression, and exacerbated oxidative stress lead to possible targets for the treatment of CAN. The present review describes the molecular alterations seen in CAN, diagnosis, and possible alternative treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza