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Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.
Smyth, Laura J; Dahlström, Emma H; Syreeni, Anna; Kerr, Katie; Kilner, Jill; Doyle, Ross; Brennan, Eoin; Nair, Viji; Fermin, Damian; Nelson, Robert G; Looker, Helen C; Wooster, Christopher; Andrews, Darrell; Anderson, Kerry; McKay, Gareth J; Cole, Joanne B; Salem, Rany M; Conlon, Peter J; Kretzler, Matthias; Hirschhorn, Joel N; Sadlier, Denise; Godson, Catherine; Florez, Jose C; Forsblom, Carol; Maxwell, Alexander P; Groop, Per-Henrik; Sandholm, Niina; McKnight, Amy Jayne.
Afiliación
  • Smyth LJ; Molecular Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
  • Dahlström EH; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
  • Syreeni A; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Kerr K; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00290, Helsinki, Finland.
  • Kilner J; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
  • Doyle R; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Brennan E; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00290, Helsinki, Finland.
  • Nair V; Molecular Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
  • Fermin D; Molecular Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
  • Nelson RG; Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
  • Looker HC; Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
  • Wooster C; Department of Medicine-Nephrology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.
  • Andrews D; Department of Pediatrics-Nephrology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.
  • Anderson K; Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA.
  • McKay GJ; Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA.
  • Cole JB; Molecular Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
  • Salem RM; Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
  • Conlon PJ; Molecular Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
  • Kretzler M; Molecular Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
  • Hirschhorn JN; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Sadlier D; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Godson C; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
  • Florez JC; Department of Nephrology and Transplantation, Beaumont Hospital and Department of Medicine Royal College of Surgeons in Ireland, Dublin 9, Ireland.
  • Forsblom C; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Maxwell AP; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
  • Groop PH; Department of Pediatrics and Genetics, Harvard Medical School, Boston, MA, USA.
  • Sandholm N; Mater Misericordiae Hospital, D07 K201, Dublin, Ireland.
  • McKnight AJ; Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
Nat Commun ; 13(1): 7891, 2022 12 22.
Article en En | MEDLINE | ID: mdl-36550108
Type 1 diabetes affects over nine million individuals globally, with approximately 40% developing diabetic kidney disease. Emerging evidence suggests that epigenetic alterations, such as DNA methylation, are involved in diabetic kidney disease. Here we assess differences in blood-derived genome-wide DNA methylation associated with diabetic kidney disease in 1304 carefully characterised individuals with type 1 diabetes and known renal status from two cohorts in the United Kingdom-Republic of Ireland and Finland. In the meta-analysis, we identify 32 differentially methylated CpGs in diabetic kidney disease in type 1 diabetes, 18 of which are located within genes differentially expressed in kidneys or correlated with pathological traits in diabetic kidney disease. We show that methylation at 21 of the 32 CpGs predict the development of kidney failure, extending the knowledge and potentially identifying individuals at greater risk for diabetic kidney disease in type 1 diabetes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 / Nefropatías Diabéticas Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 / Nefropatías Diabéticas Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido