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Structural Characterization and Spatial Mapping of Tetrodotoxins in Australian Polyclads.
McNab, Justin M; Briggs, Matthew T; Williamson, Jane E; Hoffmann, Peter; Rodriguez, Jorge; Karuso, Peter.
Afiliación
  • McNab JM; School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
  • Briggs MT; Department of Applied Biosciences, Macquarie University, Sydney, NSW 2109, Australia.
  • Williamson JE; Clinical & Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
  • Hoffmann P; School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
  • Rodriguez J; Clinical & Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
  • Karuso P; School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Mar Drugs ; 20(12)2022 Dec 19.
Article en En | MEDLINE | ID: mdl-36547935
Tetrodotoxin (TTX) is a potent marine neurotoxin that occurs in several Australian phyla, including pufferfish, toadfish, gobies, and the blue-ringed octopus. These animals are partially immune, and TTX is known to bioaccumulate and subject to trophic transfer. As such, it could be more ubiquitously distributed in animals than is currently known. Flatworms of the order Polycladida are commonly occurring invertebrates in intertidal ecosystems and are especially diverse in Australian waters. While TTX has been identified in polyclads from Japan and New Zealand, Australian species have yet to be tested. In this study, several eastern Australian polyclad flatworm species from the suborders Cotylea and Acotylea were tested for TTX and analogs by HILIC-HRMS to understand the distribution of this toxin within these suborders. Herein, we report the detection of TTX and some known analogs in polyclad species, one of which is a pest to shellfish aquaculture. We also report, for the first time, the application of MALDI mass spectrometry imaging utilized to map TTX spatially within the intestinal system of polyclads. The identification of TTX and its analogs in Australian flatworms illustrates a broader range of toxic flatworms and highlights that analogs are important to consider when studying the distributions of toxins in animals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platelmintos / Ecosistema Límite: Animals País/Región como asunto: Oceania Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platelmintos / Ecosistema Límite: Animals País/Región como asunto: Oceania Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza