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Lewis Acid Mediated Conjugate Addition of Isocyanides to ß-Hydroxy-α-diazo Carbonyls: Synthesis of ß-Carboxamido-α-diazo Carbonyl Compounds.
Liang, Yong-Xin; Wang, Jie; Xu, Xue-Cen; Gong, Yue; Zhao, Yu-Long.
Afiliación
  • Liang YX; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.
  • Wang J; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.
  • Xu XC; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.
  • Gong Y; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.
  • Zhao YL; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.
Org Lett ; 25(1): 200-204, 2023 Jan 13.
Article en En | MEDLINE | ID: mdl-36546845
A Lewis acid mediated conjugate addition of isocyanides to ß-hydroxy-α-diazo carbonyls has been developed for the first time. The reaction realizes the efficient construction of quaternary carbon centers and provides a novel and efficient strategy for the synthesis of ß-carboxamido-α-diazo carbonyls that would be otherwise difficult to form in a single step. Further applications, including synthesis of methylenecyclohexane, spiro-ß-lactam, and nitrogen-bridged tricyclic ß-lactam, demonstrated the tremendous potential of the coupling reaction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos