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Anonazepine, a new alkaloid from the leaves of Annona muricata (Annonaceae).
Huynh, Ngoc Vinh; Nguyen Huu, Duc Minh; Huynh, Ngoc Trinh; Chau, Duc Hoa; Nguyen, Cong Dinh; Nguyen Truong, Quoc Dung; Mai, Dinh Tri; Dang, Phu Hoang.
Afiliación
  • Huynh NV; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.
  • Nguyen Huu DM; Vietnam National University, Ho Chi Minh City, Vietnam.
  • Huynh NT; Faculty of Traditional Medicine, University of Medicine and Pharmacy at HCMC, Ho Chi Minh City, Vietnam.
  • Chau DH; Faculty of Pharmacy, University of Medicine and Pharmacy at HCMC, Ho Chi Minh City, Vietnam.
  • Nguyen CD; Faculty of Traditional Medicine, University of Medicine and Pharmacy at HCMC, Ho Chi Minh City, Vietnam.
  • Nguyen Truong QD; Faculty of Traditional Medicine, University of Medicine and Pharmacy at HCMC, Ho Chi Minh City, Vietnam.
  • Mai DT; Department of Health, People's Committee of Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  • Dang PH; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
Z Naturforsch C J Biosci ; 78(5-6): 247-251, 2023 May 25.
Article en En | MEDLINE | ID: mdl-36544263
From the CHCl3-soluble extract of Annona muricata L. (Annonaceae) leaves, one new 3-benzazepine-type alkaloid, anonazepine (1), and four known aporphine-type alkaloids, (+)-laurotetanine (2), (+)-norglaucine (3), (-)-xylopine (4), and lanuginosine (5), were isolated. Except for (-)-xylopine (4), these remaining known alkaloids were first reported in A. muricata. The structures of the isolated alkaloids were established by 1D and 2D NMR spectroscopy and MS, as well as comparison with literature data. The new 3-benzazepine-type alkaloid existed in an inseparable mixture of two equilibrium conformers. Its absolute configuration was determined based on comparing their experimental and calculated ECD data. The anti-inflammatory activity of the isolated alkaloids was investigated, but none of the alkaloids showed a significant result.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Annonaceae / Annona / Alcaloides / Antineoplásicos Idioma: En Revista: Z Naturforsch C J Biosci Año: 2023 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Annonaceae / Annona / Alcaloides / Antineoplásicos Idioma: En Revista: Z Naturforsch C J Biosci Año: 2023 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Alemania