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Glutamatergic neurons in lateral hypothalamus play a vital role in acupuncture preconditioning to alleviate MIRI.
Shu, Qi; Wang, Shuai-Ya; Chen, Pian-Pian; Zhang, Fan; Wang, Qian-Yi; Wei, Xia; Zhou, Jie; Zhou, Xiang; Yu, Qing; Cai, Rong-Lin.
Afiliación
  • Shu Q; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Wang SY; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Chen PP; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Zhang F; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Wang QY; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Wei X; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Zhou J; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Zhou X; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Yu Q; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
  • Cai RL; Institute of Acupuncture and Moxibustion Meridian, Medical College of Acu-Moxi, Anhui University of Chinese Medicine, Hefei, China.
J Neurophysiol ; 129(2): 320-332, 2023 02 01.
Article en En | MEDLINE | ID: mdl-36541603
Myocardial ischemia-reperfusion injury (MIRI) has high morbidity and mortality worldwide. Increasing evidence has shown that electroacupuncture (EA) plays a critical role in alleviating MIRI. The aim of this study is to investigate whether glutamatergic neurons in the lateral hypothalamus (LH) have vital effect on MIRI as well as the underlying mechanism during the EA pretreatment. The MIRI model was established by ligating the left anterior descending (LAD) coronary artery for 30 min followed by reperfusion for 2 h. Chemogenetics, electrocardiogram (ECG) recording, ELISA, multichannel physiology recording, and immunofluorescence staining methods were combined to demonstrate that firing frequencies of neurons in the LH and expression of c-Fos decreased by EA pretreatment. Meanwhile, EA preconditioning significantly reduced the percentage of infarct size and the levels of cardiac troponin I (cTnI) and creatine kinase isoenzymes (CK-MB) were similar to inhibition of glutamatergic neurons in LH, also attenuated morphology of myocardial tissue was induced by MIRI. However, activation of glutamatergic neurons in LH weakened the above effects of EA pretreatment.NEW & NOTEWORTHY This study demonstrates that EA preconditioning can attenuate myocardial injury for MIRI, which is similar to inhibition of glutamatergic neurons in LH. However, chemical activation of glutamatergic neurons in LH attenuates the protective effect of EA pretreatment. These findings help better understand the mechanisms of EA to regulate cardiac function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Electroacupuntura Límite: Humans Idioma: En Revista: J Neurophysiol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Electroacupuntura Límite: Humans Idioma: En Revista: J Neurophysiol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos