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Leptomeningeal Disease Secondary to Thr60Ala Transthyretin Amyloidosis: Case Report and Review of the Literature.
Carberry, Nathan; Yu, Sun; Fayerman, Raisy N; Dugue, Rachelle; Miller, Michael; Tanji, Kurenai; Goyal, Tarini; Canoll, Peter; Brannagan, Thomas H.
Afiliación
  • Carberry N; Department of Neurology, Neuromuscular Division, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Yu S; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA.
  • Fayerman RN; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
  • Dugue R; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
  • Miller M; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA.
  • Tanji K; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA.
  • Goyal T; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
  • Canoll P; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA.
  • Brannagan TH; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
Neurohospitalist ; 13(1): 90-95, 2023 Jan.
Article en En | MEDLINE | ID: mdl-36531853
A 31-year-old woman with transthyretin (TTR) amyloidosis secondary to a Thr60Ala mutation developed recurrent stroke-like episodes with fluctuating mental status. Evaluation for stroke and seizures was unrevealing. She was found to have leptomeningeal contrast enhancement on magnetic resonance imaging, which was confirmed to be CNS TTR amyloidosis on histopathology following brain and dura biopsy. While leptomeningeal disease has rarely been known to be associated with TTR amyloidosis, this is the first documented case of leptomeningeal disease secondary to a Thr60Ala mutation in the TTR gene. A literature review of TTR amyloidosis is presented with special focus on the treatment of leptomeningeal TTR amyloidosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurohospitalist Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurohospitalist Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos