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Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation.
Wu, Changyu; Hu, Qing; Peng, Xichun; Luo, Jianming; Zhang, Guangwen.
Afiliación
  • Wu C; Department of Food Science and Engineering, Jinan University, Guangzhou, 510632 Guangdong, China.
  • Hu Q; Department of Food Science and Engineering, Jinan University, Guangzhou, 510632 Guangdong, China.
  • Peng X; Department of Food Science and Engineering, Jinan University, Guangzhou, 510632 Guangdong, China.
  • Luo J; Department of Food Science and Engineering, Jinan University, Guangzhou, 510632 Guangdong, China.
  • Zhang G; Department of Food Science and Engineering, Jinan University, Guangzhou, 510632 Guangdong, China.
J Agric Food Chem ; 71(1): 320-330, 2023 Jan 11.
Article en En | MEDLINE | ID: mdl-36530149
The metabolic disease hyperuricemia (HUA) is characterized by a disturbance in purine metabolism. Peptides, such as marine fish-derived peptides, have previously been shown to be effective in alleviating HUA. In this study, HUA rats were induced by potassium oxonate with 100 mg/kg (L), 200 mg/kg (M), and 400 mg/kg (H) of marine fish protein peptide (MFPP). The results showed that MFPP could effectively reduce the serum uric acid (SUA) levels compared with the model group rats; kidney histopathology and the levels of inflammatory factors (TNF-α, IL-6, and IL-10) indicated that MFPP attenuated HUA-induced kidney inflammation. Meanwhile, MFPP restored the abundance of beneficial bacteria, including Lactobacillus, Blautia, Colidextribacter, and Intestinimonas. MFPP further repaired the intestinal barrier by recovering the expression of gene Ildr2 encoding the tricellular tight junction protein ILDR2 and the immune-related genes Ccr7 and Nr4a3 and also regulated the expression of Entpd8 and Cyp27b1 to restore kidney function and uric acid metabolism. MFPP was proved to have potential as a therapeutic strategy to be included in dietary intervention to relieve HUA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperuricemia / Enfermedades Intestinales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Agric Food Chem Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperuricemia / Enfermedades Intestinales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Agric Food Chem Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos