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Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development.
Chang, Yi-Cheng; Manent, Jan; Schroeder, Jan; Wong, Siew Fen Lisa; Hauswirth, Gabriel M; Shylo, Natalia A; Moore, Emma L; Achilleos, Annita; Garside, Victoria; Polo, Jose M; Trainor, Paul; McGlinn, Edwina.
Afiliación
  • Chang YC; EMBL Australia, Monash University, Clayton, Victoria, 3800, Australia.
  • Manent J; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.
  • Schroeder J; EMBL Australia, Monash University, Clayton, Victoria, 3800, Australia.
  • Wong SFL; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.
  • Hauswirth GM; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.
  • Shylo NA; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Moore EL; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Clayton, VIC, Australia.
  • Achilleos A; EMBL Australia, Monash University, Clayton, Victoria, 3800, Australia.
  • Garside V; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.
  • Polo JM; EMBL Australia, Monash University, Clayton, Victoria, 3800, Australia.
  • Trainor P; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.
  • McGlinn E; Stowers Institute for Medical Research, Kansas City, Missouri, USA.
Nat Commun ; 13(1): 7766, 2022 12 15.
Article en En | MEDLINE | ID: mdl-36522318
The vertebrate main-body axis is laid down during embryonic stages in an anterior-to-posterior (head-to-tail) direction, driven and supplied by posteriorly located progenitors. Whilst posterior expansion and segmentation appears broadly uniform along the axis, there is developmental and evolutionary support for at least two discrete modules controlling processes within different axial regions: a trunk and a tail module. Here, we identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of trunk development in the mouse. Specifically, Nr6a1 was found to control vertebral number and segmentation of the trunk region, autonomously from other axial regions. Moreover, Nr6a1 was essential for the timely progression of Hox signatures, and neural versus mesodermal cell fate choice, within axial progenitors. Collectively, Nr6a1 has an axially-restricted role in all major cellular and tissue-level events required for vertebral column formation, supporting the view that changes in Nr6a1 levels may underlie evolutionary changes in axial formulae.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vertebrados / Mesodermo Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vertebrados / Mesodermo Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido