Safety evaluation of dried L-tryptophan fermentation product in Sprague-Dawley rats.

Ko, Soo Min; Park, Ji-Eun; Kim, Sang-Ho; Park, Myeong Kyu; Seol, Ja Kyung; Heo, In Kyung; Shin, Yong-Uk; Kim, So-Young; Kim, Yang Hee; Son, Woo-Chan

Ko, Soo Min; Park, Ji-Eun; Kim, Sang-Ho; Park, Myeong Kyu; Seol, Ja Kyung; Heo, In Kyung; Shin, Yong-Uk; Kim, So-Young; Kim, Yang Hee; Son, Woo-Chan.

Afiliación

Ko SM; Department of Medical Science, Asan Medical Institute of Convergence Science and technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Park JE; CJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Kim SH; Korea Testing and Research Institute, Hwasun-gun, Jeollanam-do 58141, Republic of Korea.
Park MK; Korea Testing and Research Institute, Hwasun-gun, Jeollanam-do 58141, Republic of Korea.
Seol JK; Korea Testing and Research Institute, Hwasun-gun, Jeollanam-do 58141, Republic of Korea.
Heo IK; CJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Shin YU; CJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Kim SY; CJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Kim YH; CJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Son WC; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.

Toxicol Rep ; 9: 1099-1113, 2022.

Article en En | MEDLINE | ID: mdl-36518375

Palabras clave

BUN, blood urea nitrogen; DRF, dose range-finding; Dried L-tryptophan fermentation product; EMS, eosinophilia-myalgia syndrome; Eosinophilia-myalgia syndrome; FFPE, formalin-fixed paraffin-embedded; GHS, globally harmonized system; GLP, good laboratory practice; HED, human equivalent dose; IHC, immunohistochemistry; Metabolically engineered Corynebacterium glutamicum; NOAEL, no observed adverse effect level; OECD, Organization for Economic Cooperation and Development; Oral administration; SD, Sprague-Dawley; Subchronic toxicity; WBC, white blood cell; pAb, polyclonal antibody

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Toxicol Rep Año: 2022 Tipo del documento: Article Pais de publicación: Irlanda

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